Brand  (β version)

PDB ID: 5HES

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Ligands
Code Name Style Show Link
032 N-(3-{[5-(4-chlorophenyl)-1h-pyrrolo[2,3-B]pyridin-3-yl]carbonyl}-2,4-difluorophenyl)propane-1-sulfonamide PoSSuM
EDO 1,2-ethanediol PoSSuM
Non-standard Residues
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TPO Phosphothreonine
Glycosylation
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Structure summary

Code : 5HES   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE
Title : Human leucine zipper- and sterile alpha motif-containing kinase (ZAK, MLT, HCCS-4, MRK, AZK, MLTK) in complex with vemurafenib
Release Data : 2016-03-30
Compound :
mol_id molecule chains synonym
1 Mitogen-activated protein kinase kinase kinase MLT A,B Human cervical cancer suppressor gene 4 protein,HCCS-4,Leucine zipper- and sterile alpha motif-containing kinase,MLK-like mitogen-activated protein triple kinase,Mixed lineage kinase-related kinase,MRK,Sterile alpha motif- and leucine zipper-containing kinase AZK
ec: 2.7.11.25
fragment: UNP residues 5-309
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Spodoptera frugiperda  (taxid:7108)
gene: ZAK, MLTK, HCCS4
expression_system_common: Fall armyworm
Authors : Mathea, S., Salah, E., Abdul Azeez, K.R., Tallant, C., Szklarz, M., Chaikuad, A., Shrestha, B., Sorrell, F.J., Elkins, J.M., Shrestha, L., Burgess-Brown, N., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Knapp, S.
Keywords : Kinase, Complex, transferase
Exp. method : X-RAY DIFFRACTION ( 2.14 Å )
Citation :

Structure of the Human Protein Kinase ZAK in Complex with Vemurafenib.

Mathea, S.,Abdul Azeez, K.R.,Salah, E.  et al.
(2016)  Acs Chem.Biol.  11 : 1595 - 1602

PubMed: 26999302
DOI: 10.1021/acschembio.6b00043

Reaction

Chain : A, B
UniProt : Q9NYL2 (M3K20_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein] 2.7.11.25 PubMed:11836244, PubMed:14521931, PubMed:26999302, PubMed:32289254, PubMed:32610081, PubMed:35857590
left-to-right
ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein] 2.7.11.25 PubMed:11836244, PubMed:14521931, PubMed:26999302, PubMed:32289254, PubMed:32610081, PubMed:35857590
left-to-right PubMed:11836244, PubMed:14521931, PubMed:26999302, PubMed:32289254, PubMed:32610081, PubMed:35857590