Brand  (β version)

PDB ID: 5H4D

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Ligands
Code Name Style Show Link
ZN Zinc ion PoSSuM
MG Magnesium ion PoSSuM
BBI (2-butyl-1-benzofuran-3-yl){4-[2-(diethylamino)ethoxy]-3,5-diiodophenyl}methanone PoSSuM
NAD Nicotinamide-adenine-dinucleotide PoSSuM
MCM 7-amino-4-methyl-chromen-2-one PoSSuM
Non-standard Residues
Code Name Show
ALY N(6)-acetyllysine
Glycosylation
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Modification
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Structure summary

Code : 5H4D   PDBj   RCSB PDB   PDBe
Header : HYDROLASE
Title : Crystal structure of hSIRT3 in complex with a specific agonist Amiodarone hydrochloride
Release Data : 2017-11-08
Compound :
mol_id molecule chains synonym
1 NAD-dependent protein deacetylase sirtuin-3, mitochondrial A,H hSIRT3,Regulatory protein SIR2 homolog 3,SIR2-like protein 3
ec: 3.5.1.-
fragment: UNP residues 121-391
mol_id molecule chains
2 ARG-HIS-LYS D,C
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
gene: SIRT3, SIR2L3
mol_id organism_scientific expression_system
2 Homo sapiens  (taxid:9606) Escherichia coli  (taxid:562)
Authors : Zhang, S., Fu, L., Liu, J., Liu, B.
Keywords : SIRT3 Amiodarone agonist, HYDROLASE
Exp. method : X-RAY DIFFRACTION ( 3.2100 Å )
Citation :

Crystal structure of hSIRT3 in complex with a specific agonist Amiodarone hydrochloride

Zhang, S.,Fu, L.,Liu, J.  et al.
To Be Published 

Reaction

Chain : A, H
UniProt : Q9NTG7 (SIR3_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
H2O + N(6)-acetyl-L-lysyl-[protein] + NAD(+) = 2''-O-acetyl- ADP-D-ribose + L-lysyl-[protein] + nicotinamide 2.3.1.286 PROSITE-ProRule:PRU00236, PubMed:12186850, PubMed:12374852, PubMed:16788062, PubMed:18680753, PubMed:18794531, PubMed:19535340, PubMed:24121500, PubMed:23283301
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