Het-PDB Navi2 (PDB: 5GTR)

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Data format:

Color scheme of protein:

Ligands
Code	Name		Style	Show	Link
EST	Estradiol				PoSSuM

Non-standard Residues
Code	Name	Show
DPP	Diaminopropanoic acid
IAS	Beta-L-aspartic acid

Glycosylation
Code	Name	Emphasize

Modification
Code	Name	Show
0JY	4-methyl-L-leucine
NH2	Amino group

Download interaction data: 5GTR

Code :

5GTR PDBj RCSB PDB PDBe

Header :

TRANSCRIPTION

Title :

estrogen receptor alpha in complex with a stabilized peptide antagonist 6

Release Data :

2017-08-30

Compound :

mol_id	molecule	chains	synonym
1	Estrogen receptor	A	ER,ER-alpha,Estradiol receptor,Nuclear receptor subfamily 3 group A member 1
	fragment: UNP residues 305-547

mol_id	molecule	chains
2	ARG-IAS-ILE-0JY-DPP-ARG-0JY-0JY-GLN-NH2	C

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Homo sapiens (taxid:9606)	Human	Escherichia coli (taxid:562)
	gene: ESR1, ESR, NR3A1

mol_id	organism_scientific
2	Unidentified (taxid:32644)
	synthetic: yes

Authors :

Xie, M., Wang, T., Li, Z.-G.

Keywords :

estrogen receptor alpha, stabilized peptide, TRANSCRIPTION

Exp. method :

X-RAY DIFFRACTION ( 2.804 Å )

Citation :

Structural Basis of Inhibition of ER alpha-Coactivator Interaction by High-Affinity N-Terminus Isoaspartic Acid Tethered Helical Peptides

Xie, M.,Zhao, H.,Liu, Q. et al.
(2017) J. Med. Chem. 60 : 8731 - 8740

PDB ID: 5GTR