Brand  (β version)

PDB ID: 5GMD

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Ligands
Code Name Style Show Link
AGS Phosphothiophosphoric acid-adenylate ester PoSSuM
AMP Adenosine monophosphate PoSSuM
DP6 (3r)-3-hydroxy-5-{[(R)-hydroxy(phosphonooxy)phosphoryl]oxy}-3-methylpentanoic acid PoSSuM
SO4 Sulfate ion PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 5GMD   PDBj   RCSB PDB   PDBe
Header : LYASE
Title : Crystal structure of Sulfolobus solfataricus diphosphomevalonate decarboxylase in complex with ATP-gamma-S
Release Data : 2016-12-28
Compound :
mol_id molecule chains synonym
1 Diphosphomevalonate decarboxylase A DMD
ec: 4.1.1.33
Source :
mol_id organism_scientific expression_system
1 Sulfolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)  (taxid:273057) Escherichia coli  (taxid:562)
strain: ATCC 35092 / DSM 1617 / JCM 11322 / P2
gene: SSO2989
expression_system_vector_type: plasmid
Authors : Unno, H., Hemmi, H., Hattori, A.
Keywords : Sulfolobus solfataricus, diphosphomevalonate decarboxylase, ATPrS, LYASE
Exp. method : X-RAY DIFFRACTION ( 1.50 Å )
Citation :

A Single Amino Acid Mutation Converts (R)-5-Diphosphomevalonate Decarboxylase into a Kinase

Motoyama, K.,Unno, H.,Hattori, A.  et al.
(2017)  J. Biol. Chem.  292 : 2457 - 2469

PubMed: 28003359
DOI: 10.1074/jbc.M116.752535

Reaction

Chain : A
UniProt : Q97UL5 (DMD_SACS2)
Reaction: EC: Evidence:
Physiological Direction:
(R)-5-diphosphomevalonate + ATP = ADP + CO2 + isopentenyl diphosphate + phosphate 4.1.1.33 PubMed:23378249
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