Brand  (β version)

PDB ID: 5G6V

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Ligands
Code Name Style Show Link
919 4-[4-({[3-tert-butyl-1-(quinolin-6-yl)-1h-pyrazol-5-yl]carbamoyl}amino)-3-fluorophenoxy]-N-methylpyridine-2-carboxamide PoSSuM
EDO 1,2-ethanediol PoSSuM
Non-standard Residues
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Structure summary

Code : 5G6V   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE
Title : Crystal structure of the PCTAIRE1 kinase in complex with inhibitor
Release Data : 2016-11-23
Compound :
mol_id molecule chains synonym
1 CYCLIN-DEPENDENT KINASE 16 A,B CDK16, CELL DIVISION PROTEIN KINASE 16, PCTAIRE-MOTIF PROTEIN KINASE 1, SERINE/THREONINE-PROTEIN KINASE PCTAIRE-1
ec: 2.7.11.22
fragment: KINASE DOMAIN, RESIDUES 163-478
mutation: YES
Source :
mol_id organism_scientific organism_common expression_system
1 HOMO SAPIENS  (taxid:9606) HUMAN ESCHERICHIA COLI  (taxid:562)
Authors : Dixon-Clarke, S.E., Galan Bartual, S., Elkins, J., Savitsky, P., Kopec, J., Mackenzie, A., Tallant, C., Heroven, C., Burgess-Brown, N., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Bullock, A.
Keywords : TRANSFERASE
Exp. method : X-RAY DIFFRACTION ( 2.20 Å )
Citation :

Structure and inhibitor specificity of the PCTAIRE-family kinase CDK16.

Dixon-Clarke, S.E.,Shehata, S.N.,Krojer, T.  et al.
(2017)  Biochem.J.  474 : 699 - 713

PubMed: 28057719
DOI: 10.1042/BCJ20160941

Reaction

Chain : A, B
UniProt : Q00536 (CDK16_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein] 2.7.11.22 PubMed:22184064, PubMed:22796189, PubMed:22798068
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ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein] 2.7.11.22 PubMed:22184064, PubMed:22796189, PubMed:22798068
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