Brand  (β version)

PDB ID: 5G4C

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Ligands
Code Name Style Show Link
ZN Zinc ion PoSSuM
CNA Carba-nicotinamide-adenine-dinucleotide PoSSuM
Non-standard Residues
Code Name Show
6G4 4-oxononanoyl lysine
Glycosylation
Code Name Emphasize
Modification
Code Name Show

Structure summary

Code : 5G4C   PDBj   RCSB PDB   PDBe
Header : HYDROLASE
Title : Human SIRT2 catalyse short chain fatty acyl lysine
Release Data : 2017-05-03
Compound :
mol_id molecule chains synonym
1 NAD-DEPENDENT PROTEIN DEACETYLASE SIRTUIN-2 A,B REGULATORY PROTEIN SIR2 HOMOLOG 2, SIR2-LIKE PROTEIN 2
ec: 3.5.1.-
fragment: CATALYTIC DOMAIN, RESIDUES 34-356
mol_id molecule chains
2 SIRT2 E,F
Source :
mol_id organism_scientific organism_common expression_system
1 HOMO SAPIENS  (taxid:9606) HUMAN ESCHERICHIA COLI  (taxid:469008)
gene: SIRT2, SIR2L, SIR2L2
expression_system_strain: BL21(DE3)
expression_system_variant: ROSETTA
expression_system_vector_type: PLASMID
expression_system_plasmid: PET28-SUMO
mol_id organism_scientific organism_common expression_system
2 HOMO SAPIENS  (taxid:9606) HUMAN ESCHERICHIA COLI  (taxid:469008)
expression_system_strain: BL21(DE3)
expression_system_variant: ROSETTA
expression_system_vector_type: PLASMID
expression_system_plasmid: PET28-SUMO
Authors : Wang, Y.
Keywords : HYDROLASE, SIRTUIN CLASS I, HDACS, NAD DEPENDENT, ADPR, ACYL
Exp. method : X-RAY DIFFRACTION ( 2.1 Å )
Citation :

SIRT2 Reverses 4-Oxononanoyl Lysine Modification on Histones.

Jin, J.,He, B.,Zhang, X.  et al.
(2016)  J. Am. Chem. Soc.  138 : 12304 - 12307

PubMed: 27610633
DOI: 10.1021/jacs.6b04977

Reaction

Chain : A, B
UniProt : Q8IXJ6 (SIR2_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
H2O + N(6)-acetyl-L-lysyl-[protein] + NAD(+) = 2''-O-acetyl- ADP-D-ribose + L-lysyl-[protein] + nicotinamide 2.3.1.286 PROSITE-ProRule:PRU00236, PubMed:11483616, PubMed:11812793, PubMed:16648462, PubMed:18722353, PubMed:24177535, PubMed:24389023, PubMed:24940000, PubMed:25672491
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H2O + N(6)-tetradecanoyl-L-lysyl-[protein] + NAD(+) = 2''-O- tetradecanoyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide - PubMed:25704306, PubMed:32103017
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H2O + N(6)-hexadecanoyl-L-lysyl-[protein] + NAD(+) = 2''-O- hexadecanoyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide - PubMed:29239724
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