Brand  (β version)

PDB ID: 5FZI

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Ligands
Code Name Style Show Link
CL Chloride ion PoSSuM
DMS Dimethyl sulfoxide PoSSuM
EDO 1,2-ethanediol PoSSuM
FIG 6-oxo-2-[(2-oxo-2-phenylethyl)sulfanyl]-1,6-dihydropyrimidine-5-carboxylic acid PoSSuM
MN Manganese (II) ion PoSSuM
PO4 Phosphate ion PoSSuM
ZN Zinc ion PoSSuM
Non-standard Residues
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Structure summary

Code : 5FZI   PDBj   RCSB PDB   PDBe
Header : OXIDOREDUCTASE
Title : Crystal structure of the catalytic domain of human JARID1B in complex with MC3095
Release Data : 2017-03-29
Compound :
mol_id molecule chains synonym
1 LYSINE-SPECIFIC DEMETHYLASE 5B A CANCER/TESTIS ANTIGEN 31, CT31, HISTONE DEMETHYLASE JARID1B, JUMONJI/ARID DOMAIN-CONTAINING PROTEIN 1B, PLU-1, RETINOBLASTOMA-BINDING PROTEIN 2 HOMOLOG 1, RBP2-H1
ec: 1.14.11.-
fragment: JMJC DOMAIN, RESIDUES 26-101,374-770
Source :
mol_id organism_scientific organism_common expression_system
1 HOMO SAPIENS  (taxid:9606) HUMAN SPODOPTERA FRUGIPERDA  (taxid:7108)
expression_system_common: FALL ARMYWORM
expression_system_cell_line: SF9
expression_system_vector_type: BACULOVIRUS
expression_system_plasmid: PFB-LIC-BSE
Authors : Nowak, R., Kopec, J., Johansson, C., Gileadi, C., Kupinska, K., Strain-Damerell, C., Szykowska, A., von Delft, F., Burgess-Brown, N.A., Arrowsmith, C.H., Bountra, C., Edwards, A.M., Rotili, D., Mai, A., Oppermann, U.
Keywords : OXIDOREDUCTASE, JARID1B, PLU1
Exp. method : X-RAY DIFFRACTION ( 1.950 Å )
Citation :

Crystal Structure of the Catalytic Domain of Human Jarid1B in Complex with Mc3095

Nowak, R.,Kopec, J.,Johansson, C.  et al.
To be Published 

Reaction

Chain : A
UniProt : Q9UGL1 (KDM5B_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
N(6),N(6),N(6)-trimethyl-L-lysyl(4)-[histone H3] + 3 2- oxoglutarate + 3 O2 = L-lysyl(4)-[histone H3] + 3 formaldehyde + 3 succinate + 3 CO2 1.14.11.67 UniProtKB:Q80Y84
-
Cofactor: Evidence: Note:
Fe(2+) ECO:0000250
Binds 1 Fe(2+) ion per subunit.