Het-PDB Navi2 (PDB: 5FYX)

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Data format:

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Ligands
Code	Name	Link
CA	Calcium ion	PoSSuM
FD6	N-[2-(2-chloranylphenothiazin-10-yl)ethyl]-4-methyl-piperazin-1-amine	PoSSuM
MPD	(4s)-2-methyl-2,4-pentanediol	PoSSuM

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Download interaction data: 5FYX

Code :

5FYX PDBj RCSB PDB PDBe

Header :

CALCIUM-BINDING PROTEIN

Title :

Crystal structure of Drosophila NCS-1 bound to penothiazine FD16

Release Data :

2017-01-25

Compound :

mol_id	molecule	chains
1	FREQUENIN 2	A
	mutation: YES

Source :

mol_id	organism_scientific	organism_common	expression_system
1	DROSOPHILA MELANOGASTER (taxid:7227)	FRUIT FLY	ESCHERICHIA COLI (taxid:469008)
	expression_system_strain: BL21(DE3) expression_system_vector_type: PLASMID expression_system_vector: PETDUET-1

Authors :

Martinez-Gonzalez, L., Chaves-Sanjuan, A., Infantes, L., Sanchez-Barrena, M.J.

Keywords :

CALCIUM SENSOR, CALCIUM-BINDING PROTEIN

Exp. method :

X-RAY DIFFRACTION ( 1.800 Å )

Citation :

Interference of the complex between NCS-1 and Ric8a with phenothiazines regulates synaptic function and is an approach for fragile X syndrome.

Mansilla, A.,Chaves-Sanjuan, A.,Campillo, N.E. et al.
(2017) Proc. Natl. Acad. Sci. U.S.A. 114 : E999 - E1008

PDB ID: 5FYX