Brand  (β version)

PDB ID: 5FL4

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Ligands
Code Name Style Show Link
ZN Zinc ion PoSSuM
9FK 5-(1-naphthalen-1-yl-1,2,3-triazol-4-yl)thiophene-2-sulfonamide PoSSuM
GOL Glycerol PoSSuM
ACY Acetic acid PoSSuM
Non-standard Residues
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Structure summary

Code : 5FL4   PDBj   RCSB PDB   PDBe
Header : LYASE
Title : Three dimensional structure of human carbonic anhydrase IX in complex with 5-(1-naphthalen-1-yl-1,2,3-triazol-4-yl)thiophene-2-sulfonamide
Release Data : 2015-11-11
Compound :
mol_id molecule chains synonym
1 CARBONIC ANHYDRASE 9 A,B,C,D CARBONATE DEHYDRATASE IX, CARBONIC ANHYDRASE IX, CA-IX, CAIX, MEMBRANE ANTIGEN MN, P54/58N, RENAL CELL CARCINOMA-ASSOCIATED ANTIGEN G250, RCC-ASSOCIATED ANTIGEN G250, PMW1
ec: 4.2.1.1
fragment: UNP RESIDUES 137-391
mutation: YES
Source :
mol_id organism_scientific organism_common expression_system
1 HOMO SAPIENS  (taxid:9606) HUMAN KOMAGATAELLA PASTORIS  (taxid:4922)
Authors : Leitans, J., Tars, K., Zalubovskis, R.
Keywords : LYASE
Exp. method : X-RAY DIFFRACTION ( 1.82 Å )
Citation :

An Efficient Expression and Crystallization System of the Cancer Asociated Carbonic Anhydrase Isoform Ix.

Leitans, J.,Kazaks, A.,Balode, A.  et al.
(2015)  J.Med.Chem.  58 : 9004

PubMed: 26522624
DOI: 10.1021/ACS.JMEDCHEM.5B01343

Reaction

Chain : A, B, C, D
UniProt : Q16790 (CAH9_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
hydrogencarbonate + H(+) = CO2 + H2O 4.2.1.1 PubMed:17314045, PubMed:17705204, PubMed:18703501, PubMed:19186056, PubMed:19206230, PubMed:19805286
right-to-left PubMed:18703501
Cofactor: Evidence: Note:
Zn(2+) ECO:0000269 | PubMed:18703501
ECO:0000269 | PubMed:19805286
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