Brand  (β version)

PDB ID: 5FDG

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Ligands
Code Name Style Show Link
0N8 (2z)-4-[1-benzyl-4-(4-chlorobenzyl)piperidin-4-yl]-2-hydroxy-4-oxobut-2-enoic acid PoSSuM
MN Manganese (II) ion PoSSuM
SO4 Sulfate ion PoSSuM
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Structure summary

Code : 5FDG   PDBj   RCSB PDB   PDBe
Header : HYDROLASE/HYDROLASE INHIBITOR
Title : Endonuclease inhibitor 3 bound to influenza strain H1N1 polymerase acidic subunit N-terminal region at pH 7.0
Release Data : 2015-12-30
Compound :
mol_id molecule chains synonym
1 Polymerase acidic protein A RNA-directed RNA polymerase subunit P2
fragment: endonuclease, residues 1-50, 73-196
Source :
mol_id organism_scientific expression_system
1 Influenza A virus  (taxid:211044) Escherichia coli  (taxid:562)
strain: A/Puerto Rico/8/1934 H1N1
gene: PA
expression_system_strain: Rosetta (DE3) pLysS
expression_system_vector_type: plasmid
expression_system_plasmid: pET50b(+)
Authors : Fudo, S., Yamamoto, N., Nukaga, M., Odagiri, T., Tashiro, M., Hoshino, T.
Keywords : Hydrolase-Hydrolase Inhibitor complex
Exp. method : X-RAY DIFFRACTION ( 2.100 Å )
Citation :

Two Distinctive Binding Modes of Endonuclease Inhibitors to the N-Terminal Region of Influenza Virus Polymerase Acidic Subunit

Fudo, S.,Yamamoto, N.,Nukaga, M.  et al.
(2016)  Biochemistry  55 : 2646 - 2660

PubMed: 27088785
DOI: 10.1021/acs.biochem.5b01087

Reaction

Chain : A
UniProt : P03433 (PA_I34A1)
Reaction : -
Cofactor: Evidence: Note:
Mn(2+) ECO:0000255 | HAMAP-Rule:MF_04063
ECO:0000269 | PubMed:19194459
ECO:0000269 | PubMed:26252962
ECO:0000269 | PubMed:27088785
Binds 2 manganese ions per subunit.