Het-PDB Navi2 (PDB: 5FDG)

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Ligands
Code	Name	Link
0N8	(2z)-4-[1-benzyl-4-(4-chlorobenzyl)piperidin-4-yl]-2-hydroxy-4-oxobut-2-enoic acid	PoSSuM
MN	Manganese (II) ion	PoSSuM
SO4	Sulfate ion	PoSSuM

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Download interaction data: 5FDG

Code :

5FDG PDBj RCSB PDB PDBe

Header :

HYDROLASE/HYDROLASE INHIBITOR

Title :

Endonuclease inhibitor 3 bound to influenza strain H1N1 polymerase acidic subunit N-terminal region at pH 7.0

Release Data :

2015-12-30

Compound :

mol_id	molecule	chains	synonym
1	Polymerase acidic protein	A	RNA-directed RNA polymerase subunit P2
	fragment: endonuclease, residues 1-50, 73-196

Source :

mol_id	organism_scientific	expression_system
1	Influenza A virus (taxid:211044)	Escherichia coli (taxid:562)
	strain: A/Puerto Rico/8/1934 H1N1 gene: PA expression_system_strain: Rosetta (DE3) pLysS expression_system_vector_type: plasmid expression_system_plasmid: pET50b(+)

Authors :

Fudo, S., Yamamoto, N., Nukaga, M., Odagiri, T., Tashiro, M., Hoshino, T.

Keywords :

Hydrolase-Hydrolase Inhibitor complex

Exp. method :

X-RAY DIFFRACTION ( 2.100 Å )

Citation :

Two Distinctive Binding Modes of Endonuclease Inhibitors to the N-Terminal Region of Influenza Virus Polymerase Acidic Subunit

Fudo, S.,Yamamoto, N.,Nukaga, M. et al.
(2016) Biochemistry 55 : 2646 - 2660

PDB ID: 5FDG