Het-PDB Navi2 (PDB: 5F9T)

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Ligands
Code	Name		Style	Show	Link
FSI	5-acetamido-3,5-dideoxy-3-fluoro-D-erythro-alpha-L-manno-non-2-ulopyranosonic acid				PoSSuM
SFJ	(2r,3r,4r,5r,6r)-5-acetamido-2,3-difluoro-4-hydroxy-6-[(1r,2r)-1,2,3-trihydroxypropyl]tetrahydro-2h-pyran-2-carboxylic acid				PoSSuM

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Download interaction data: 5F9T

Code :

5F9T PDBj RCSB PDB PDBe

Header :

HYDROLASE

Title :

Crystal Structure of Streptococcus pneumoniae NanC, covalent complex with a fluorinated Neu5Ac derivative

Release Data :

2015-12-23

Compound :

mol_id	molecule	chains	synonym
1	Neuraminidase C	A,B	Putative neuraminidase
	ec: 3.2.1.18

Source :

mol_id	organism_scientific	expression_system
1	Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4) (taxid:170187)	Escherichia coli BL21(DE3) (taxid:469008)
	strain: ATCC BAA-334 / TIGR4 gene: SP_1326 expression_system_vector_type: plasmid expression_system_plasmid: pET21b

Authors :

Owen, C.D., Lukacik, P., Potter, J.A., Walsh, M., Taylor, G.L.

Keywords :

Sialidase, Neuraminidase, covalent intermediate, CBM40, hydrolase

Exp. method :

X-RAY DIFFRACTION ( 2.0500 Å )

Citation :

Streptococcus pneumoniae NanC: STRUCTURAL INSIGHTS INTO THE SPECIFICITY AND MECHANISM OF A SIALIDASE THAT PRODUCES A SIALIDASE INHIBITOR.

Owen, C.D.,Lukacik, P.,Potter, J.A. et al.
(2015) J.Biol.Chem. 290 : 27736 - 27748

PDB ID: 5F9T