Het-PDB Navi2 (PDB: 5F20)

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Ligands
Code	Name		Style	Show	Link
5U4	3-azanyl-5-(2-methylphenyl)-7-(1-methylpyrazol-3-yl)-1~{H}-pyrazolo[4,3-C]pyridin-4-one				PoSSuM

Non-standard Residues
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Glycosylation
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Download interaction data: 5F20

Code :

5F20 PDBj RCSB PDB PDBe

Header :

TRANSFERASE/TRANSFERASE INHIBITOR

Title :

Structure of TYK2 with inhibitor 4: 3-azanyl-5-(2-methylphenyl)-7-(1-methylpyrazol-3-yl)-1~{H}-pyrazolo[4,3-C]pyridin-4-one

Release Data :

2016-01-13

Compound :

mol_id	molecule	chains
1	Non-receptor tyrosine-protein kinase TYK2	A
	ec: 2.7.10.2

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Homo sapiens (taxid:9606)	Human	Unidentified baculovirus (taxid:10469)
	gene: TYK2

Authors :

Skene, R.J.

Keywords :

kinase, TRANSFERASE-TRANSFERASE INHIBITOR complex

Exp. method :

X-RAY DIFFRACTION ( 2.9100 Å )

Citation :

Structure-Based Design and Synthesis of 3-Amino-1,5-dihydro-4H-pyrazolopyridin-4-one Derivatives as Tyrosine Kinase 2 Inhibitors.

Yogo, T.,Nagamiya, H.,Seto, M. et al.
(2016) J.Med.Chem. 59 : 733 - 749

Chain :

UniProt :

P29597 (TYK2_HUMAN)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl- [protein]	2.7.10.2	PubMed:10542297, PubMed:7526154
	-	PubMed:10542297, PubMed:7526154

PDB ID: 5F20