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Ligands
Code Name Style Show Link
NA Sodium ion
5SL ~{N}-[(1~{S},3~{S})-3-[3-[(4-methylphenyl)methyl]-1,2,4-oxadiazol-5-yl]cyclopentyl]-1~{H}-pyrazolo[3,4-D]pyrimidin-4-amine
Non-standard Residues
Code Name Show
Glycosylation
Code Name Emphasize
NAG 2-acetamido-2-deoxy-beta-D-glucopyranose
BMA Beta-D-mannopyranose
MAN Alpha-D-mannopyranose
Modification
Code Name Show
Code : 5EWL   PDBj   RCSB PDB   PDBe
Header : TRANSPORT PROTEIN
Title : CRYSTAL STRUCTURE OF AMINO TERMINAL DOMAINS OF THE NMDA RECEPTOR SUBUNIT GLUN1 AND GLUN2B IN COMPLEX WITH MK-22
Release Data : 2016-03-02
Compound :
mol_id molecule chains
1 NMDA glutamate receptor subunit A,C
fragment: Amino Terminal Domain (UNP residues 23-408)
mutation: N61Q,N371Q
mol_id molecule chains synonym
2 Glutamate receptor ionotropic, NMDA 2B B,D GluN2B,Glutamate [NMDA] receptor subunit epsilon-2,N-methyl D-aspartate receptor subtype 2B,NR2B,N-methyl-D-aspartate receptor subunit 3,hNR3
fragment: Amino Terminal Domain (UNP residues 31-394)
mutation: N348D
Source :
mol_id organism_scientific organism_common expression_system
1 Xenopus laevis  (taxid:8355) African clawed frog Spodoptera frugiperda  (taxid:7108)
gene: grin1, NR1
expression_system_common: Fall armyworm
expression_system_vector_type: baculovirus
mol_id organism_scientific organism_common expression_system
2 Homo sapiens  (taxid:9606) Human Spodoptera frugiperda  (taxid:7108)
gene: GRIN2B, NMDAR2B
expression_system_common: Fall armyworm
expression_system_vector_type: baculovirus
Authors : Pandit, J.
Keywords : NMDA Receptor, allosteric inhibition, GluN2B subunit, TRANSPORT PROTEIN
Exp. method : X-RAY DIFFRACTION ( 2.98 Å )
Citation :

A Novel Binding Mode Reveals Two Distinct Classes of NMDA Receptor GluN2B-selective Antagonists.

Stroebel, D.,Buhl, D.L.,Knafels, J.D.  et al.
(2016)  Mol.Pharmacol.  89 : 541 - 551

PubMed: 26912815
DOI: 10.1124/mol.115.103036

Chain : A, C
UniProt : Q91977 (NMDZ1_XENLA)
Reaction : -
Chain : B, D
UniProt : Q13224 (NMDE2_HUMAN)
Reaction : -