Brand  (β version)

PDB ID: 5EW8

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Ligands
Code Name Style Show Link
SO4 Sulfate ion PoSSuM
5SF ~{N}'-(3,5-dimethoxyphenyl)-~{N}'-[3-(1-methylpyrazol-4-yl)quinoxalin-6-yl]-~{N}-propan-2-yl-ethane-1,2-diamine PoSSuM
Non-standard Residues
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Structure summary

Code : 5EW8   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE
Title : FIBROBLAST GROWTH FACTOR RECEPTOR 1 IN COMPLEX WITH JNJ-4275693
Release Data : 2016-03-30
Compound :
mol_id molecule chains synonym
1 Fibroblast growth factor receptor 1 A,B FGFR-1,Basic fibroblast growth factor receptor 1,bFGF-R-1,Fms-like tyrosine kinase 2,FLT-2,N-sam,Proto-oncogene c-Fgr
ec: 2.7.10.1
fragment: UNP residues 458-765
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
gene: FGFR1, BFGFR, CEK, FGFBR, FLG, FLT2, HBGFR
Authors : Ogg, D., Breed, J.
Keywords : FGFR1 KINASE INHIBITOR COMPLEX, KINASE, transferase
Exp. method : X-RAY DIFFRACTION ( 1.63 Å )
Citation :

Landscape of activating cancer mutations in FGFR kinases and their differential responses to inhibitors in clinical use.

Patani, H.,Bunney, T.D.,Thiyagarajan, N.  et al.
(2016)  Oncotarget  7 : 24252 - 24268

PubMed: 26992226
DOI: 10.18632/oncotarget.8132

Reaction

Chain : A, B
UniProt : P11362 (FGFR1_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+) 2.7.10.1 PROSITE-ProRule:PRU10028, PubMed:1379697, PubMed:15117958, PubMed:18480409, PubMed:19224897, PubMed:19665973, PubMed:20133753, PubMed:8622701
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