Brand  (β version)

PDB ID: 5EU9

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Ligands
Code Name Style Show Link
MG Magnesium ion PoSSuM
5TX ((3s,5s)-1,5-dihydroxy-3-methyl-2-oxopyrrolidin-3-yl)phosphonic acid PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 5EU9   PDBj   RCSB PDB   PDBe
Header : LYASE/LYASE INHIBITOR
Title : Structure of Human Enolase 2 in complex with ((3S,5S)-1,5-dihydroxy-3-methyl-2-oxopyrrolidin-3-yl)phosphonic acid
Release Data : 2016-11-23
Compound :
mol_id molecule chains synonym
1 Gamma-enolase A,B,C,D,E,F,G,H 2-phospho-D-glycerate hydro-lyase, Enolase 2, Neural enolase, Neuron-specific enolase, NSE
ec: 4.2.1.11
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli BL21  (taxid:511693)
gene: ENO2
expression_system_strain: Rosetta2 plysS
expression_system_vector_type: plasmid
expression_system_plasmid: pJL-H6
Authors : Leonard, P.G., Muller, F.L.
Keywords : enolase gamma, glycolysis, neuron specific enolase, carbohydrate metabolism, LYASE-LYASE INHIBITOR complex
Exp. method : X-RAY DIFFRACTION ( 2.0470 Å )
Citation :

SF2312, a natural phosphonate inhibitor of Enolase

Leonard, P.G.,Maxwell, D.,Satani, N.  et al.
To be Published 

Reaction

Chain : A, B, C, D, E, F, G, H
UniProt : P09104 (ENOG_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
(2R)-2-phosphoglycerate = phosphoenolpyruvate + H2O 4.2.1.11 -
-
Cofactor: Evidence: Note:
Mg(2+) - Mg(2+) is required for catalysis and for stabilizing the dimer.