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Ligands
Code Name Style Show Link
APC Diphosphomethylphosphonic acid adenosyl ester
5RX 2-azanyl-8-[(4-chlorophenyl)methylsulfanyl]-1,9-dihydropurin-6-one
NA Sodium ion
MG Magnesium ion
Non-standard Residues
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Code : 5ETS   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE/TRANSFERASE inhibitor
Title : S. aureus 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase complexed with AMPCPP and inhibitor at 1.95 angstrom resolution
Release Data : 2016-05-04
Compound :
mol_id molecule chains
1 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase B,A
ec: 2.7.6.3
Source :
mol_id organism_scientific expression_system
1 Staphylococcus aureus  (taxid:1280) Escherichia coli  (taxid:562)
gene: RK60_02090, RK67_01645, RK72_06915, RK74_04210, RK75_00240, RK80_01970, RK83_05435, RK84_03130, RK95_04415, RK96_04825, RK98_03440, RK99_07885, RL05_10010, RL06_09555, RL08_05305, TM59_02255
Authors : Dennis, M.L., Peat, T.S., Swarbrick, J.D.
Keywords : inhibitor, complex, ampcpp, pyrophosphokinase, TRANSFERASE-TRANSFERASE inhibitor complex
Exp. method : X-RAY DIFFRACTION ( 1.95 Å )
Citation :

Structural Basis for the Selective Binding of Inhibitors to 6-Hydroxymethyl-7,8-dihydropterin Pyrophosphokinase from Staphylococcus aureus and Escherichia coli.

Dennis, M.L.,Pitcher, N.P.,Lee, M.D.  et al.
(2016)  J.Med.Chem.  59 : 5248 - 5263

PubMed: 27094768
DOI: 10.1021/acs.jmedchem.6b00002

Chain : B, A
UniProt : A0A0H1ZSM1
Reaction : -