Brand  (β version)

PDB ID: 5ES1

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Ligands
Code Name Style Show Link
5RC ~{N}-[(1~{R},6~{R})-6-azanyl-2,2-bis(fluoranyl)cyclohexyl]-5-ethyl-4-[6-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-3-yl]thiophene-2-carboxamide PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 5ES1   PDBj   RCSB PDB   PDBe
Header : Transferase/Transferase Inhibitor
Title : CRYSTAL STRUCTURE OF MICROTUBULE AFFINITY-REGULATING KINASE 4 CATALYTIC DOMAIN IN COMPLEX WITH A PYRAZOLOPYRIMIDINE INHIBITOR
Release Data : 2015-12-02
Compound :
mol_id molecule chains synonym
1 MAP/microtubule affinity-regulating kinase 4 A MAP/microtubule affinity-regulating kinase-like 1
ec: 2.7.11.1
fragment: CATALYTIC AND UBA DOMAINS, RESIDUES 44-370
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:469008)
gene: MARK4, KIAA1860, MARKL1
expression_system_strain: BL21/DE3
expression_system_plasmid: pET16B
Authors : Sack, J.S.
Keywords : MARK4 PAR-1 SERINE/THREONINE PROTEIN KINASE11, Transferase-Transferase Inhibitor complex
Exp. method : X-RAY DIFFRACTION ( 2.80 Å )
Citation :

Crystal structure of microtubule affinity-regulating kinase 4 catalytic domain in complex with a pyrazolopyrimidine inhibitor.

Sack, J.S.,Gao, M.,Kiefer, S.E.  et al.
(2016)  Acta Crystallogr F Struct Biol Commun  72 : 129 - 134

PubMed: 26841763
DOI: 10.1107/S2053230X15024747

Reaction

Chain : A
UniProt : Q96L34 (MARK4_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein] 2.7.11.1 PubMed:14594945, PubMed:15009667, PubMed:23184942
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ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein] 2.7.11.1 PubMed:14594945, PubMed:15009667, PubMed:23184942
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