Brand  (β version)

PDB ID: 5EQH

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Ligands
Code Name Style Show Link
5RF (2~{S})-3-(2-bromophenyl)-2-[2-(4-methoxyphenyl)ethanoylamino]-~{N}-[(1~{S})-1-phenylethyl]propanamide PoSSuM
Non-standard Residues
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Structure summary

Code : 5EQH   PDBj   RCSB PDB   PDBe
Header : TRANSPORT PROTEIN/INHIBITOR
Title : Human GLUT1 in complex with inhibitor (2~{S})-3-(2-bromophenyl)-2-[2-(4-methoxyphenyl)ethanoylamino]-~{N}-[(1~{S})-1-phenylethyl]propanamide
Release Data : 2016-04-13
Compound :
mol_id molecule chains synonym
1 Solute carrier family 2, facilitated glucose transporter member 1 A Glucose transporter type 1, erythrocyte/brain, GLUT-1, HepG2 glucose transporter
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Saccharomyces cerevisiae  (taxid:4932)
gene: SLC2A1, GLUT1
expression_system_common: Yeast
expression_system_strain: DSY-5
Authors : Kapoor, K., Finer-Moore, J., Pedersen, B.P., Caboni, L., Waight, A.B., Hillig, R., Bringmann, P., Heisler, I., Muller, T., Siebeneicher, H., Stroud, R.M.
Keywords : MFS transporter, glucose transporter, TRANSPORT PROTEIN-INHIBITOR complex
Exp. method : X-RAY DIFFRACTION ( 2.99 Å )
Citation :

Mechanism of inhibition of human glucose transporter GLUT1 is conserved between cytochalasin B and phenylalanine amides.

Kapoor, K.,Finer-Moore, J.S.,Pedersen, B.P.  et al.
(2016)  Proc.Natl.Acad.Sci.USA  113 : 4711 - 4716

PubMed: 27078104
DOI: 10.1073/pnas.1603735113

Reaction

Chain : A
UniProt : P11166 (GTR1_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
D-glucose(out) = D-glucose(in) - PubMed:10227690, PubMed:25982116, PubMed:27078104
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