Het-PDB Navi2 (PDB: 5EP7)

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Ligands
Code	Name		Style	Show	Link
5QR	3-[(1-methyl-6-oxidanylidene-pyridin-3-yl)carbonylamino]benzoic acid				PoSSuM

Non-standard Residues
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Glycosylation
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Download interaction data: 5EP7

Code :

5EP7 PDBj RCSB PDB PDBe

Header :

TRANSFERASE

Title :

Crystal structure of the bromodomain of human CREBBP in complex with UN32

Release Data :

2016-11-23

Compound :

mol_id	molecule	chains
1	CREB-binding protein	A
	ec: 2.3.1.48 fragment: UNP residues 1081-1197

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Homo sapiens (taxid:9606)	Human	Escherichia coli BL21(DE3) (taxid:469008)
	gene: CREBBP, CBP expression_system_vector_type: plasmid expression_system_plasmid: pNIC28-Bsa4

Authors :

Dong, J., Caflisch, A.

Keywords :

Transcription, INHIBITOR, transferase

Exp. method :

X-RAY DIFFRACTION ( 1.1980 Å )

Citation :

Binding Motifs in the CBP Bromodomain: An Analysis of 20 Crystal Structures of Complexes with Small Molecules.

Zhu, J.,Dong, J.,Batiste, L. et al.
(2018) ACS Med Chem Lett 9 : 929 - 934

Chain :

UniProt :

Q92793 (CBP_HUMAN)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
acetyl-CoA + L-lysyl-[histone] = CoA + H(+) + N(6)-acetyl-L- lysyl-[histone]	2.3.1.48	PubMed:24616510
	left-to-right	PubMed:24616510
acetyl-CoA + L-lysyl-[protein] = CoA + H(+) + N(6)-acetyl-L- lysyl-[protein]	-	PubMed:11154691, PubMed:12738767, PubMed:24207024, PubMed:24939902, PubMed:30540930, PubMed:35675826
	left-to-right	PubMed:11154691, PubMed:12738767, PubMed:24207024, PubMed:24939902, PubMed:28790157, PubMed:30540930, PubMed:35675826

PDB ID: 5EP7