Brand  (β version)

PDB ID: 5EOL

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Ligands
Code Name Style Show Link
5QO Macrocyclic quinoxaline-pyrrolodihydropiperidinone PoSSuM
GOL Glycerol PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 5EOL   PDBj   RCSB PDB   PDBe
Header : transferase/transferase inhibitor
Title : Crystal structure of human Pim-1 kinase in complex with a macrocyclic quinoxaline-pyrrolodihydropiperidinone inhibitor
Release Data : 2016-05-04
Compound :
mol_id molecule chains
1 Serine/threonine-protein kinase pim-1 A
ec: 2.7.11.1
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
gene: PIM1
Authors : Mohr, C.
Keywords : TRANSFERASE, serine/threonine protein kinase, transferase-transferase inhibitor complex
Exp. method : X-RAY DIFFRACTION ( 2.20 Å )
Citation :

Discovery and Optimization of Macrocyclic Quinoxaline-pyrrolo-dihydropiperidinones as Potent Pim-1/2 Kinase Inhibitors.

Cee, V.J.,Chavez, F.,Herberich, B.  et al.
(2016)  Acs Med.Chem.Lett.  7 : 408 - 412

PubMed: 27096050
DOI: 10.1021/acsmedchemlett.5b00403

Reaction

Chain : A
UniProt : P11309 (PIM1_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+) 2.7.11.1 PubMed:15525646, PubMed:15657054, PubMed:15808862, PubMed:31548394, PubMed:37797010
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L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+) 2.7.11.1 PubMed:15525646, PubMed:15657054, PubMed:15808862, PubMed:37797010
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Cofactor: Evidence: Note:
Mg(2+) ECO:0000269 | PubMed:15525646
ECO:0000269 | PubMed:15657054
ECO:0000269 | PubMed:15808862
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