Brand  (β version)

PDB ID: 5EHX

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Ligands
Code Name Style Show Link
03S Methanesulfonic acid PoSSuM
AE4 3,6,9,12,15-pentaoxaheptadecan-1-ol PoSSuM
Non-standard Residues
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Glycosylation
Code Name Emphasize
NAG 2-acetamido-2-deoxy-beta-D-glucopyranose
Modification
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Structure summary

Code : 5EHX   PDBj   RCSB PDB   PDBe
Header : HYDROLASE
Title : Crystal structure of MSF-aged Torpedo californica Acetylcholinesterase
Release Data : 2016-11-09
Compound :
mol_id molecule chains synonym
1 Acetylcholinesterase A AChE
ec: 3.1.1.7
Source :
mol_id organism_scientific organism_common
1 Torpedo californica  (taxid:7787) Pacific electric ray
Authors : Pesaresi, A., Lamba, D.
Keywords : alpha beta hydrolase, irreversible inhibitor, hydrolase
Exp. method : X-RAY DIFFRACTION ( 2.1000 Å )
Citation :

Disentangling the formation, mechanism, and evolvement of the covalent methanesulfonyl fluoride acetylcholinesterase adduct: Insights into an aged-like inactive complex susceptible to reactivation by a combination of nucleophiles.

Stojan, J.,Pesaresi, A.,Meden, A.  et al.
(2024)  Protein Sci.  33 : e4977 - e4977

PubMed: 38591646
DOI: 10.1002/pro.4977

Reaction

Chain : A
UniProt : P04058 (ACES_TETCF)
Reaction: EC: Evidence:
Physiological Direction:
acetylcholine + H2O = choline + acetate + H(+) 3.1.1.7 -
-