Brand  (β version)

PDB ID: 5E58

Hetero Atom Contents

  The number of atoms exceeds 100,000.
  So, it can not be displayed here.

Select unit:

Select hetatm:   

close
information
centroid:
interaction residue:

Select chain:   Sequence  

Data format:   

Color scheme of protein:

Ligands
Code Name Style Show Link
HEM Protoporphyrin ix containing Fe PoSSuM
CPZ 4-(4-chlorophenyl)imidazole PoSSuM
CM5 5-cyclohexyl-1-pentyl-beta-D-maltoside PoSSuM
GOL Glycerol PoSSuM
GLC Alpha-D-glucopyranose PoSSuM
FRU Beta-D-fructofuranose PoSSuM
: Polysaccharide
Non-standard Residues
Code Name Show
Glycosylation
Code Name Emphasize
Modification
Code Name Show

Structure summary

Code : 5E58   PDBj   RCSB PDB   PDBe
Header : OXIDOREDUCTASE
Title : Crystal Structure Of Cytochrome P450 2B35 from Desert Woodrat Neotoma Lepida in complex with 4-(4-chlorophenyl)imidazole
Release Data : 2016-02-10
Compound :
mol_id molecule chains
1 Cytochrome P450 family 2 subfamily B A,B,C,D,E,F
Source :
mol_id organism_scientific organism_common expression_system
1 Neotoma lepida  (taxid:56216) Desert woodrat Escherichia coli  (taxid:562)
gene: CYP2B
expression_system_strain: C43(DE3)
expression_system_plasmid: pKK
Authors : Shah, M.B., Stout, C.D., Halpert, J.R.
Keywords : Cytochrome P450; CYP2B35; Neotoma Lepida; Woodrat, OXIDOREDUCTASE
Exp. method : X-RAY DIFFRACTION ( 2.40 Å )
Citation :

Structure-Function Analysis of Mammalian CYP2B Enzymes Using 7-Substituted Coumarin Derivatives as Probes: Utility of Crystal Structures and Molecular Modeling in Understanding Xenobiotic Metabolism.

Shah, M.B.,Liu, J.,Huo, L.  et al.
(2016)  Mol.Pharmacol.  89 : 435 - 445

PubMed: 26826176
DOI: 10.1124/mol.115.102111

Reaction

Chain : A, B, C, D, E, F
UniProt : J9JD66 (J9JD66_NEOLE)
Reaction: EC: Evidence:
Physiological Direction:
an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] 1.14.14.1 RuleBase:RU368046
-