Brand  (β version)

PDB ID: 5E0E

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Ligands
Code Name Style Show Link
CPZ 4-(4-chlorophenyl)imidazole PoSSuM
HEM Protoporphyrin ix containing Fe PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 5E0E   PDBj   RCSB PDB   PDBe
Header : Oxidoreductase/Oxidoreductase inhibitor
Title : Crystal Structure of Cytochrome P450 2B37 from Desert Woodrat in complex with 4-(4-chlorophenyl)imidazole
Release Data : 2016-02-10
Compound :
mol_id molecule chains
1 Cytochrome P450 family 2 subfamily B A
fragment: UNP residues 29-491
Source :
mol_id organism_scientific organism_common expression_system
1 Neotoma lepida  (taxid:56216) Desert woodrat Escherichia coli  (taxid:562)
gene: CYP2B
expression_system_strain: C43 (DE3)
expression_system_plasmid: pKK
Authors : Shah, M.B., Halpert, J.R., Stout, C.D.
Keywords : Cytochrome P450, CYP2B37, 4-(4-chlorophenyl)imidazole, Inhibitor, Oxidoreductase-Oxidoreductase inhibitor complex
Exp. method : X-RAY DIFFRACTION ( 3.40 Å )
Citation :

Structure-Function Analysis of Mammalian CYP2B Enzymes Using 7-Substituted Coumarin Derivatives as Probes: Utility of Crystal Structures and Molecular Modeling in Understanding Xenobiotic Metabolism.

Shah, M.B.,Liu, J.,Huo, L.  et al.
(2016)  Mol.Pharmacol.  89 : 435 - 445

PubMed: 26826176
DOI: 10.1124/mol.115.102111

Reaction

Chain : A
UniProt : J9JD75 (J9JD75_NEOLE)
Reaction: EC: Evidence:
Physiological Direction:
an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] 1.14.14.1 RuleBase:RU368046
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