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Ligands
Code Name Style Show Link
0HK (1r,2r,4s,5s,7s)-7-{[hydroxy(dithiophen-2-yl)acetyl]oxy}-9,9-dimethyl-3-oxa-9-azoniatricyclo[3.3.1.0~2,4~]nonane
OLA Oleic acid
EDT {[-(bis-carboxymethyl-amino)-ethyl]-carboxymethyl-amino}-acetic acid
P6G Hexaethylene glycol
OLC (2r)-2,3-dihydroxypropyl (9z)-octadec-9-enoate
Non-standard Residues
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Code : 5DSG   PDBj   RCSB PDB   PDBe
Header : MEMBRANE PROTEIN
Title : Structure of the M4 muscarinic acetylcholine receptor (M4-mT4L) bound to tiotropium
Release Data : 2016-03-16
Compound :
mol_id molecule chains synonym
1 Muscarinic acetylcholine receptor M4,Endolysin,Endolysin,Muscarinic acetylcholine receptor M4 A,B Lysis protein,Lysozyme,Muramidase,Lysis protein,Lysozyme,Muramidase
ec: 3.2.1.17,3.2.1.17
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Spodoptera frugiperda  (taxid:7108)
gene: CHRM4
Authors : Thal, D.M., Kobilka, B.K., Sexton, P.M., Christopoulos, A.
Keywords : Membrane, GPCR, Signaling, Antagonist, MEMBRANE PROTEIN
Exp. method : X-RAY DIFFRACTION ( 2.6000 Å )
Citation :

Crystal structures of the M1 and M4 muscarinic acetylcholine receptors.

Thal, D.M.,Sun, B.,Feng, D.  et al.
(2016)  Nature  531 : 335 - 340

PubMed: 26958838
DOI: 10.1038/nature17188

Chain : A, B
UniProt : P08173 (ACM4_HUMAN)
Reaction : -
Chain : A, B
UniProt : P00720 (ENLYS_BPT4)
Reaction: EC: Evidence:
Physiological Direction:
Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins. 3.2.1.17 HAMAP-Rule:MF_04110, PubMed:4865643
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