Het-PDB Navi2 (PDB: 5DQ8)

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Ligands
Code	Name		Style	Show	Link
FLF	2-[[3-(trifluoromethyl)phenyl]amino] benzoic acid				PoSSuM

Non-standard Residues
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Download interaction data: 5DQ8

Code :

5DQ8 PDBj RCSB PDB PDBe

Header :

TRANSCRIPTION

Title :

Crystal structure of human transcription factor TEAD2 in complex with flufenamic acid

Release Data :

2015-11-25

Compound :

mol_id	molecule	chains	synonym
1	Transcriptional enhancer factor TEF-4	A,B	TEA domain family member 2,TEAD-2
	fragment: residues 217-447

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Homo sapiens (taxid:9606)	Human	Escherichia coli (taxid:469008)
	gene: TEAD2, TEF4 expression_system_strain: BL21(DE3) expression_system_vector_type: plasmid expression_system_plasmid: pET29

Authors :

Han, X., Luo, X.

Keywords :

flufenamates, cancer therapy, Hippo pathway, TRANSCRIPTION

Exp. method :

X-RAY DIFFRACTION ( 2.305 Å )

Citation :

Targeting the Central Pocket in Human Transcription Factor TEAD as a Potential Cancer Therapeutic Strategy.

Pobbati, A.V.,Han, X.,Hung, A.W. et al.
(2015) Structure 23 : 2076 - 2086

PDB ID: 5DQ8