Brand  (β version)

PDB ID: 5DED

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Ligands
Code Name Style Show Link
0O2 Guanosine 5'-(tetrahydrogen triphosphate) 3'-(trihydrogen diphosphate) PoSSuM
MG Magnesium ion PoSSuM
Non-standard Residues
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Structure summary

Code : 5DED   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE
Title : Crystal structure of the small alarmone synthethase 1 from Bacillus subtilis bound to its product pppGpp
Release Data : 2015-10-28
Compound :
mol_id molecule chains synonym
1 GTP pyrophosphokinase YjbM D,A,B,C,E,F,G,H (p)ppGpp synthase YjbM,Small alarmone synthase 1,SAS 1
ec: 2.7.6.5
Source :
mol_id organism_scientific expression_system
1 Bacillus subtilis PY79  (taxid:1415167) Escherichia coli BL21(DE3)  (taxid:469008)
strain: 168
gene: yjbM, BSU11600
expression_system_plasmid: pET24d(+)
Authors : Steinchen, W., Schuhmacher, J.S., Altegoer, F., Bange, G.
Keywords : (p)ppGpp, alarmone, stringent response, allosteric regulator, transferase
Exp. method : X-RAY DIFFRACTION ( 2.942 Å )
Citation :

Catalytic mechanism and allosteric regulation of an oligomeric (p)ppGpp synthetase by an alarmone.

Steinchen, W.,Schuhmacher, J.S.,Altegoer, F.  et al.
(2015)  Proc.Natl.Acad.Sci.USA  112 : 13348 - 13353

PubMed: 26460002
DOI: 10.1073/pnas.1505271112

Reaction

Chain : D, A, B, C, E, F, G, H
UniProt : O31611 (YJBM_BACSU)
Reaction: EC: Evidence:
Physiological Direction:
ATP + GTP = AMP + guanosine 3'-diphosphate 5'-triphosphate 2.7.6.5 PubMed:26460002
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ATP + GDP = AMP + guanosine 3',5'-bis(diphosphate) - PubMed:26460002
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