Het-PDB Navi2 (PDB: 5D8U)

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Ligands
Code	Name		Style	Show	Link
0N8	(2z)-4-[1-benzyl-4-(4-chlorobenzyl)piperidin-4-yl]-2-hydroxy-4-oxobut-2-enoic acid				PoSSuM
MN	Manganese (II) ion				PoSSuM

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Download interaction data: 5D8U

Code :

5D8U PDBj RCSB PDB PDBe

Header :

HYDROLASE/HYDROLASE INHIBITOR

Title :

2009 H1N1 PA endonuclease mutant E119D in complex with L-742,001

Release Data :

2016-03-16

Compound :

mol_id	molecule	chains	synonym
1	Polymerase acidic protein	A	PA endonuclease
	fragment: endonuclease domain (UNP residues 1-50, 73-196 connected by GGS linker) mutation: E119D

Source :

mol_id	organism_scientific	expression_system
1	Influenza A virus (taxid:641501)	Escherichia coli BL21(DE3) (taxid:469008)
	strain: swl A/California/04/2009 H1N1 gene: PA expression_system_vector_type: plasmid expression_system_plasmid: pET52b

Authors :

Kumar, G., White, S.W.

Keywords :

influenza, resistance, endonuclease inhibitor, viral protein, HYDROLASE-HYDROLASE INHIBITOR complex

Exp. method :

X-RAY DIFFRACTION ( 2.2900 Å )

Citation :

Identification and characterization of influenza variants resistant to a viral endonuclease inhibitor.

Song, M.S.,Kumar, G.,Shadrick, W.R. et al.
(2016) Proc.Natl.Acad.Sci.USA 113 : 3669 - 3674

PDB ID: 5D8U