Brand  (β version)

color scheme of protein:

hetatm:

x
information
centroid:
interaction residue:

chain:

Ligands
Code Name Link
0N8 (2z)-4-[1-benzyl-4-(4-chlorobenzyl)piperidin-4-yl]-2-hydroxy-4-oxobut-2-enoic acid
MN Manganese (II) ion
Code : 5D8U
Header : HYDROLASE/HYDROLASE INHIBITOR
Title : 2009 H1N1 PA endonuclease mutant E119D in complex with L-742,001
Release Data : 2016-03-16
Compound :
mol_id molecule chains synonym
1 Polymerase acidic protein A PA endonuclease
fragment: endonuclease domain (UNP residues 1-50, 73-196 connected by GGS linker)
mutation: E119D
Source :
mol_id organism_scientific expression_system
1 Influenza A virus  (taxid:641501) Escherichia coli BL21(DE3)  (taxid:469008)
strain: swl A/California/04/2009 H1N1
gene: PA
expression_system_vector_type: plasmid
expression_system_plasmid: pET52b
Authors : Kumar, G., White, S.W.
Keywords : influenza, resistance, endonuclease inhibitor, viral protein, HYDROLASE-HYDROLASE INHIBITOR complex
Exp. method : X-RAY DIFFRACTION ( 2.2900 Å )
Citation :

Identification and characterization of influenza variants resistant to a viral endonuclease inhibitor.

Song, M.S.,Kumar, G.,Shadrick, W.R.  et al.
(2016)  Proc.Natl.Acad.Sci.USA  113 : 3669 - 3674

PubMed: 26976575
DOI: 10.1073/pnas.1519772113

Chain : A
UniProt : C3W5S0 (No found in current UniProtKB/SwissProt)
Reaction : -