Brand  (β version)

PDB ID: 5D6E

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Ligands
Code Name Style Show Link
94A (4r,7s)-7-hydroxy-1-(4-methoxybenzyl)-7-methyl-4,5,6,7-tetrahydro-1h-benzotriazol-4-yl propan-2-ylcarbamate PoSSuM
CO Cobalt (II) ion PoSSuM
TBU Tertiary-butyl alcohol PoSSuM
Non-standard Residues
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Structure summary

Code : 5D6E   PDBj   RCSB PDB   PDBe
Header : HYDROLASE
Title : Structure of human methionine aminopeptidase 2 with covalent spiroepoxytriazole inhibitor (-)-31b
Release Data : 2016-01-13
Compound :
mol_id molecule chains synonym
1 Methionine aminopeptidase 2 A MetAP 2,Initiation factor 2-associated 67 kDa glycoprotein,p67eIF2,Peptidase M
ec: 3.4.11.18
fragment: UNP residues 108-478
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Spodoptera frugiperda  (taxid:7108)
gene: METAP2, MNPEP, P67EIF2
expression_system_common: Fall armyworm
expression_system_vector_type: baculovirus
Authors : Janowski, R., Miller, A.K., Niessing, D.
Keywords : Methionine aminopeptidase 2, Spiroepoxytriazoles, inhibitor, hydrolase
Exp. method : X-RAY DIFFRACTION ( 1.49 Å )
Citation :

Spiroepoxytriazoles Are Fumagillin-like Irreversible Inhibitors of MetAP2 with Potent Cellular Activity.

Morgen, M.,Jost, C.,Malz, M.  et al.
(2016)  Acs Chem.Biol.  11 : 1001 - 1011

PubMed: 26686773
DOI: 10.1021/acschembio.5b00755

Reaction

Chain : A
UniProt : P50579 (MAP2_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
Release of N-terminal amino acids, preferentially methionine, from peptides and arylamides. 3.4.11.18 HAMAP-Rule:MF_03175, PubMed:20521764
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