Het-PDB Navi2 (PDB: 5D3F)

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Ligands
Code	Name		Style	Show	Link
FSC	Fusicoccin				PoSSuM

Non-standard Residues
Code	Name	Show
SEP	Phosphoserine

Glycosylation
Code	Name	Emphasize

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Download interaction data: 5D3F

Code :

5D3F PDBj RCSB PDB PDBe

Header :

SIGNALING PROTEIN

Title :

Crystal structure of human 14-3-3 zeta in complex with CFTR R-domain peptide pS753-pS768 and stabilizer fusicoccin-A

Release Data :

2016-03-16

Compound :

mol_id	molecule	chains	synonym
1	14-3-3 protein zeta/delta	A,B	Protein kinase C inhibitor protein 1,KCIP-1

mol_id	molecule	chains	synonym
2	Cystic fibrosis transmembrane conductance regulator	C	CFTR,ATP-binding cassette sub-family C member 7,Channel conductance-controlling ATPase,cAMP-dependent chloride channel
	ec: 3.6.3.49 fragment: UNP residues 747-774

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Homo sapiens (taxid:9606)	Human	Escherichia coli (taxid:562)
	gene: YWHAZ

mol_id	organism_scientific	organism_common
2	Homo sapiens (taxid:9606)	Human
	synthetic: yes

Authors :

Stevers, L.M., Leysen, S.F.R., Ottmann, C.

Keywords :

signaling protein, protein-peptide complex, phosphorylation, tandem binding, stabilization, fusicoccin-A, Structural Genomics, Eindhoven University of Technology

Exp. method :

X-RAY DIFFRACTION ( 2.740 Å )

Citation :

Characterization and small-molecule stabilization of the multisite tandem binding between 14-3-3 and the R domain of CFTR.

Stevers, L.M.,Lam, C.V.,Leysen, S.F. et al.
(2016) Proc.Natl.Acad.Sci.USA 113 : E1152 - E1161

PubMed: 26888287
DOI: 10.1073/pnas.1516631113

Chain :	A, B
UniProt :	P63104 (1433Z_HUMAN)
Reaction :	-

PDB ID: 5D3F

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