Brand  (β version)

PDB ID: 5CQU

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Ligands
Code Name Style Show Link
GOL Glycerol PoSSuM
JRJ 4-[4-[2-[4,5,6,7-tetrakis(bromanyl)benzotriazol-2-yl]ethyl]-1,2,3-triazol-1-yl]butan-1-amine PoSSuM
SO4 Sulfate ion PoSSuM
Non-standard Residues
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Structure summary

Code : 5CQU   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE
Title : Monoclinic Complex Structure of Protein Kinase CK2 Catalytic Subunit with a Benzotriazole-Based Inhibitor Generated by click-chemistry
Release Data : 2015-09-09
Compound :
mol_id molecule chains synonym
1 Casein kinase II subunit alpha A CK II alpha
ec: 2.7.11.1
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli BL21(DE3)  (taxid:469008)
gene: CSNK2A1, CK2A1
expression_system_vector_type: plasmid
expression_system_plasmid: PT7-7
Authors : Niefind, K., Schnitzler, A., Swider, R., Maslyk, M., Ramos, A.
Keywords : TRANSFERASE, ATP-COMPETITIVE INHIBITOR, Protein kinase CK2, casein kinase 2
Exp. method : X-RAY DIFFRACTION ( 2.350 Å )
Citation :

Synthesis, Biological Activity and Structural Study of New Benzotriazole-Based Protein Kinase CK2 Inhibitors

Swider, R.,Maslyk, M.,Zapico, J.M.  et al.
(2015)  Rsc Adv  5 : 72482 - 72494

DOI: 10.1039/C5RA12114K

MULTISITE-DIRECTED INHIBITORS OF PROTEIN KINASE CK2: NEW CHALLENGES

Swider, R.,Maslyk, M.,Martin-Santamaria, S.  et al.
(2011)  Mol. Cell. Biochem.  356 : 117 - 119

PubMed: 21750979
DOI: 10.1007/S11010-011-0962-7

Reaction

Chain : A
UniProt : P68400 (CSK21_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein] 2.7.11.1 PubMed:20545769, PubMed:20625391, PubMed:21482717, PubMed:22184066, PubMed:23123191, PubMed:30699359, PubMed:30898438, PubMed:31439799
left-to-right PubMed:20545769, PubMed:21482717, PubMed:23123191, PubMed:30699359, PubMed:30898438, PubMed:31439799, PubMed:35597237
ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein] 2.7.11.1 PubMed:20625391, PubMed:22325354, PubMed:31439799
left-to-right PubMed:31439799