Brand  (β version)

PDB ID: 5CI3

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Ligands
Code Name Style Show Link
FEO Mu-oxo-diiron PoSSuM
SO4 Sulfate ion PoSSuM
Non-standard Residues
Code Name Show
FY3 2,3,5-trifluoro-L-tyrosine
Glycosylation
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Modification
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Structure summary

Code : 5CI3   PDBj   RCSB PDB   PDBe
Header : OXIDOREDUCTASE
Title : Ribonucleotide reductase Y122 2,3,5-F3Y variant
Release Data : 2016-07-13
Compound :
mol_id molecule chains synonym
1 Ribonucleoside-diphosphate reductase 1 subunit beta A Protein B2,Protein R2,Ribonucleotide reductase 1
ec: 1.17.4.1
mutation: Y122(FY3)
Source :
mol_id organism_scientific expression_system
1 Escherichia coli O157:H7  (taxid:83334) Escherichia coli BL21(DE3)  (taxid:469008)
gene: nrdB, ftsB, Z3491, ECs3118
Authors : Funk, M.A., Drennan, C.L.
Keywords : unnatural amino acid, fluorotyrosine, ferritin superfamily, metalloenzyme, OXIDOREDUCTASE
Exp. method : X-RAY DIFFRACTION ( 2.401 Å )
Citation :

Biophysical Characterization of Fluorotyrosine Probes Site-Specifically Incorporated into Enzymes: E. coli Ribonucleotide Reductase As an Example.

Oyala, P.H.,Ravichandran, K.R.,Funk, M.A.  et al.
(2016)  J.Am.Chem.Soc.  138 : 7951 - 7964

PubMed: 27276098
DOI: 10.1021/jacs.6b03605

Reaction

Chain : A
UniProt : P69925 (RIR2_ECO57)
Reaction: EC: Evidence:
Physiological Direction:
[thioredoxin]-disulfide + a 2'-deoxyribonucleoside 5'- diphosphate + H2O = [thioredoxin]-dithiol + a ribonucleoside 5'- diphosphate 1.17.4.1 PROSITE-ProRule:PRU10014
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