Het-PDB Navi2 (PDB: 5CHV)

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Ligands
Code	Name	Link
ZN	Zinc ion	PoSSuM
SO4	Sulfate ion	PoSSuM
CL	Chloride ion	PoSSuM

Non-standard Residues
Code	Name	Show

Glycosylation
Code	Name	Emphasize

Modification
Code	Name	Show
AYE	Prop-2-en-1-amine

Download interaction data: 5CHV

Code :

5CHV PDBj RCSB PDB PDBe

Header :

HYDROLASE

Title :

Crystal structure of USP18-ISG15 complex

Release Data :

2016-09-28

Compound :

mol_id	molecule	chains	synonym
1	Ubl carboxyl-terminal hydrolase 18	A,B	43 kDa ISG15-specific protease,ISG15-specific-processing protease,Ubl thioesterase 18
	ec: 3.4.19.- fragment: UNP residues 46-368 other_details: The protein was expressed without the N-terminal 45 residues. The construct contains residues 46-368 out of 368 residues.

mol_id	molecule	chains	synonym
2	Ubiquitin-like protein ISG15	C,D	Interferon-induced 15 kDa protein,Interferon-induced 17 kDa protein,IP17,Ubiquitin cross-reactive protein
	fragment: UNP residues 1-155 other_details: In ISG15 chain C the terminal Glycine 155 is replaced by a propargylamine that reacts with the active site Cysteine 61 of USP18 chain A and forms a covalent bond.

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Mus musculus (taxid:10090)	Mouse	Spodoptera frugiperda (taxid:7108)
	gene: Usp18, Ubp43 expression_system_common: Fall armyworm expression_system_cell_line: Sf21 expression_system_vector_type: MultiBac

mol_id	organism_scientific	organism_common	expression_system
2	Mus musculus (taxid:10090)	Mouse	Escherichia coli (taxid:562)
	gene: Isg15, G1p2, Ucrp expression_system_vector_type: MultiBac expression_system_plasmid: pTXB1

Authors :

Fritz, G., Basters, A.

Keywords :

Ubiquitin-specific protease, ISG15, interferon, hydrolase

Exp. method :

X-RAY DIFFRACTION ( 3.005 Å )

Citation :

Structural basis of the specificity of USP18 toward ISG15.

Basters, A.,Geurink, P.P.,Rocker, A. et al.
(2017) Nat. Struct. Mol. Biol. 24 : 270 - 278

Chain :

A, B

UniProt :

Q9WTV6 (UBP18_MOUSE)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76- residue protein attached to proteins as an intracellular targeting signal).	3.4.19.12	UniProtKB:Q9UMW8
	-	UniProtKB:Q9UMW8

PDB ID: 5CHV