Brand  (β version)

PDB ID: 5CGV

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Ligands
Code Name Style Show Link
0N8 (2z)-4-[1-benzyl-4-(4-chlorobenzyl)piperidin-4-yl]-2-hydroxy-4-oxobut-2-enoic acid PoSSuM
GOL Glycerol PoSSuM
MN Manganese (II) ion PoSSuM
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Structure summary

Code : 5CGV   PDBj   RCSB PDB   PDBe
Header : HYDROLASE/HYDROLASE INHIBITOR
Title : 2009 H1N1 PA endonuclease in complex with L-742,001
Release Data : 2016-03-23
Compound :
mol_id molecule chains
1 Polymerase acidic protein A
fragment: residues 1-196
Source :
mol_id organism_scientific expression_system
1 Influenza A virus  (taxid:641501) Escherichia coli  (taxid:469008)
strain: swl A/California/04/2009 H1N1
gene: PA
expression_system_strain: BL21(DE3)
expression_system_vector_type: plasmid
expression_system_plasmid: pET52b
Authors : Kumar, G., White, S.W.
Keywords : Influenza Resistance Endonuclease Inhibitor, HYDROLASE-HYDROLASE INHIBITOR complex
Exp. method : X-RAY DIFFRACTION ( 2.17 Å )
Citation :

Identification and characterization of influenza variants resistant to a viral endonuclease inhibitor.

Song, M.S.,Kumar, G.,Shadrick, W.R.  et al.
(2016)  Proc. Natl. Acad. Sci. U.S.A.  113 : 3669 - 3674

PubMed: 26976575
DOI: 10.1073/pnas.1519772113

Reaction

Chain : A
UniProt : C3W5S0 (PA_I09A0)
Reaction : -
Cofactor: Evidence: Note:
Mn(2+) ECO:0000255 | HAMAP-Rule:MF_04063
ECO:0000269 | PubMed:22876177
ECO:0000269 | PubMed:26976575
ECO:0000269 | PubMed:27510745
ECO:0000269 | PubMed:29215062
Binds 2 manganese ions per subunit.