Brand  (β version)

PDB ID: 5CCS

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Ligands
Code Name Style Show Link
C4Y 1-(4-aminobenzyl)-3-{2-oxo-2-[(2r)-2-phenylpyrrolidin-1-yl]ethyl}urea PoSSuM
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Structure summary

Code : 5CCS   PDBj   RCSB PDB   PDBe
Header : ISOMERASE
Title : Human Cyclophilin D Complexed with Inhibitor
Release Data : 2016-07-20
Compound :
mol_id molecule chains synonym
1 Peptidyl-prolyl cis-trans isomerase F, mitochondrial X PPIase F,Cyclophilin D,CypD,Cyclophilin F,Mitochondrial cyclophilin,CyP-M,Rotamase F, Human Cyclophilin D
ec: 5.2.1.8
fragment: UNP residues 44-207
mutation: K125Q K133I
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli BL21(DE3)  (taxid:469008)
gene: PPIF, CYP3
expression_system_vector_type: plasmid
expression_system_plasmid: pET28b
Authors : Gibson, R.P., Shore, E., Kershaw, N., Awais, M., Javed, A., Latawiec, D., Pandalaneni, S., Wen, L., Berry, N., O'Neill, P., Sutton, R., Lian, L.Y.
Keywords : Cyclophilin, isomerase, complex, inhibitor
Exp. method : X-RAY DIFFRACTION ( 2.10 Å )
Citation :

Human Cyclophilin D Complexed with Inhibitor

Gibson, R.P.,Shore, E.,Kershaw, N.  et al.
To Be Published 

Reaction

Chain : X
UniProt : P30405 (PPIF_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
[protein]-peptidylproline (omega=180) = [protein]- peptidylproline (omega=0) 5.2.1.8 PubMed:20676357
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