Brand  (β version)

PDB ID: 5C5P

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Ligands
Code Name Style Show Link
ZN Zinc ion PoSSuM
0E0 (3r)-3-(1-hydroxy-2-methylpropan-2-yl)-1,3,4,5-tetrahydro-6h-pyrano[4,3-C]isoquinolin-6-one PoSSuM
SO4 Sulfate ion PoSSuM
Non-standard Residues
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Structure summary

Code : 5C5P   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE/TRANSFERASE INHIBITOR
Title : CRYSTAL STRUCTURE OF HUMAN TANKYRASE-2 IN COMPLEX WITH A PYRANOPYRIDONE INHIBITOR
Release Data : 2015-08-12
Compound :
mol_id molecule chains synonym
1 Tankyrase-2 A,B TANK2,ADP-ribosyltransferase diphtheria toxin-like 6,ARTD6,Poly [ADP-ribose] polymerase 5B,TNKS-2,TRF1-interacting ankyrin-related ADP-ribose polymerase 2,Tankyrase II,Tankyrase-like protein,Tankyrase-related protein
ec: 2.4.2.30
fragment: UNP RESIDUES 946-1113
mol_id molecule chains synonym
2 Tankyrase-2 C,D TANK2,ADP-ribosyltransferase diphtheria toxin-like 6,ARTD6,Poly [ADP-ribose] polymerase 5B,TNKS-2,TRF1-interacting ankyrin-related ADP-ribose polymerase 2,Tankyrase II,Tankyrase-like protein,Tankyrase-related protein
ec: 2.4.2.30
fragment: UNP RESIDUES 1114-1162
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
gene: TNKS2, PARP5B, TANK2, TNKL
mol_id organism_scientific organism_common expression_system
2 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
gene: TNKS2, PARP5B, TANK2, TNKL
Authors : Lukacs, C.M., Janson, C.A.
Keywords : WNT-SIGNALLING, BETA-CATENIN, PARP-DOMAIN, ADP-RIBOSYLATION, AXIN, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
Exp. method : X-RAY DIFFRACTION ( 1.75 Å )
Citation :

Fragment-Based Drug Design of Novel Pyranopyridones as Cell Active and Orally Bioavailable Tankyrase Inhibitors.

de Vicente, J.,Tivitmahaisoon, P.,Berry, P.  et al.
(2015)  Acs Med.Chem.Lett.  6 : 1019 - 1024

PubMed: 26396691
DOI: 10.1021/acsmedchemlett.5b00251

Reaction

Chain : C, D
UniProt : Q9H2K2 (TNKS2_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
NAD(+) + (ADP-D-ribosyl)n-acceptor = nicotinamide + (ADP-D- ribosyl)n+1-acceptor + H(+). 2.4.2.30 PubMed:19759537, PubMed:21478859
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L-aspartyl-[protein] + NAD(+) = 4-O-(ADP-D-ribosyl)-L- aspartyl-[protein] + nicotinamide - ECO:0000305
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L-glutamyl-[protein] + NAD(+) = 5-O-(ADP-D-ribosyl)-L- glutamyl-[protein] + nicotinamide - ECO:0000305
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