Het-PDB Navi2 (PDB: 5BPU)

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Ligands
Code	Name		Style	Show	Link

Non-standard Residues
Code	Name	Show
GGL	Gamma-L-glutamic acid

Glycosylation
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Download interaction data: 5BPU

Code :

5BPU PDBj RCSB PDB PDBe

Header :

SIGNALING PROTEIN

Title :

Crystal structure of Norrin, a Wnt signalling activator, Crystal Form I

Release Data :

2015-07-01

Compound :

mol_id	molecule	chains	synonym
1	Norrin	A,B,C,D,E,F	Norrie disease protein,X-linked exudative vitreoretinopathy 2 protein
	fragment: residues 25-133

mol_id	molecule	chains
2	(GGL)EEEEEE	H

mol_id	molecule	chains
3	(GGL)EEE	I

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Homo sapiens (taxid:9606)	Human	Homo sapiens (taxid:9606)
	gene: NDP, EVR2 expression_system_common: Human expression_system_cell_line: HEK293T expression_system_vector_type: Plasmid expression_system_plasmid: pHLIgK-STR-8H-SUMO-1D4

mol_id	organism_scientific
2	Synthetic construct (taxid:32630)
	synthetic: yes

mol_id	organism_scientific
3	Synthetic construct (taxid:32630)
	synthetic: yes

Authors :

Chang, T.-H., Hsieh, F.-L., Harlos, K., Jones, E.Y.

Keywords :

Wnt signalling pathway, Norrie disease protein, cystine-knot like growth factor, ligand for Frizzled 4 receptor, SIGNALING PROTEIN

Exp. method :

X-RAY DIFFRACTION ( 2.4000 Å )

Citation :

Structure and functional properties of Norrin mimic Wnt for signalling with Frizzled4, Lrp5/6, and proteoglycan.

Chang, T.H.,Hsieh, F.L.,Zebisch, M. et al.
(2015) Elife 4 : e06554

PDB ID: 5BPU