Brand  (β version)

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Modified Residues
Code Name Link
GGL Gamma-L-glutamic acid
Code : 5BPU   PDBj   RCSB PDB   PDBe
Header : SIGNALING PROTEIN
Title : Crystal structure of Norrin, a Wnt signalling activator, Crystal Form I
Release Data : 2015-07-01
Compound :
mol_id molecule chains synonym
1 Norrin A,B,C,D,E,F Norrie disease protein,X-linked exudative vitreoretinopathy 2 protein
fragment: residues 25-133
mol_id molecule chains
2 (GGL)EEEEEE H
mol_id molecule chains
3 (GGL)EEE I
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Homo sapiens  (taxid:9606)
gene: NDP, EVR2
expression_system_common: Human
expression_system_cell_line: HEK293T
expression_system_vector_type: Plasmid
expression_system_plasmid: pHLIgK-STR-8H-SUMO-1D4
mol_id organism_scientific
2 Synthetic construct  (taxid:32630)
synthetic: yes
mol_id organism_scientific
3 Synthetic construct  (taxid:32630)
synthetic: yes
Authors : Chang, T.-H., Hsieh, F.-L., Harlos, K., Jones, E.Y.
Keywords : Wnt signalling pathway, Norrie disease protein, cystine-knot like growth factor, ligand for Frizzled 4 receptor, SIGNALING PROTEIN
Exp. method : X-RAY DIFFRACTION ( 2.4000 Å )
Citation :

Structure and functional properties of Norrin mimic Wnt for signalling with Frizzled4, Lrp5/6, and proteoglycan.

Chang, T.H.,Hsieh, F.L.,Zebisch, M.  et al.
(2015)  Elife  4 : e06554

PubMed: 26158506
DOI: 10.7554/eLife.06554

Chain : A, B, C, D, E, F
UniProt : Q00604 (NDP_HUMAN)
Reaction : -