Brand  (β version)

PDB ID: 5AQO

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Ligands
Code Name Style Show Link
GOL Glycerol PoSSuM
CWS 6-methylquinazolin-4-amine PoSSuM
TRS 2-amino-2-hydroxymethyl-propane-1,3-diol PoSSuM
DMS Dimethyl sulfoxide PoSSuM
CL Chloride ion PoSSuM
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Structure summary

Code : 5AQO   PDBj   RCSB PDB   PDBe
Header : CHAPERONE
Title : Fragment-based screening of HSP70 sheds light on the functional role of ATP-binding site residues
Release Data : 2016-10-05
Compound :
mol_id molecule chains synonym
1 HEAT SHOCK COGNATE 71 KDA PROTEIN A,C,E HEAT SHOCK 70 KDA PROTEIN 8, LIPOPOLYSACCHARIDE-ASSOCIATED PROTEIN 1, LAP-1, LPS-ASSOCIATED PROTEIN 1
ec: 3.6.3.51
fragment: NUCLEOTIDE BINDING DOMAIN RESIDUES 1-381
mol_id molecule chains synonym
2 BAG FAMILY MOLECULAR CHAPERONE REGULATOR 1 B,D,F BAG-1, BCL-2-ASSOCIATED ATHANOGENE 1
fragment: RESIDUES 222 TO 334
Source :
mol_id organism_scientific organism_common expression_system
1 HOMO SAPIENS  (taxid:9606) HUMAN ESCHERICHIA COLI  (taxid:511693)
expression_system_strain: BL21
expression_system_variant: AI
expression_system_vector_type: PLASMID
expression_system_plasmid: PGEX-6P-1
mol_id organism_scientific organism_common expression_system
2 HOMO SAPIENS  (taxid:9606) HUMAN ESCHERICHIA COLI  (taxid:511693)
expression_system_strain: BL21
expression_system_variant: AI
expression_system_vector_type: PLASMID
expression_system_plasmid: PGEX-6P-1
Authors : Jones, A.M., Westwood, I.M., Osborne, J.D., Matthews, T.P., Cheeseman, M.D., Rowlands, M.G., Jeganathan, F., Burke, R., Lee, D., Kadi, N., Liu, M., Richards, M., McAndrew, C., Yahya, N., Dobson, S.E., Jones, K., Workman, P., Collins, I., van Montfort, R.L.M.
Keywords : HEAT SHOCK PROTEIN, HSP70, HSP72, HSC70, ATPASE, BAG1, CHAPERONE, FRAGMENT
Exp. method : X-RAY DIFFRACTION ( 2.12 Å )
Citation :

A fragment-based approach applied to a highly flexible target: Insights and challenges towards the inhibition of HSP70 isoforms.

Jones, A.M.,Westwood, I.M.,Osborne, J.D.  et al.
(2016)  Sci Rep  6 : 34701 - 34701

PubMed: 27708405
DOI: 10.1038/srep34701

Reaction

Chain : A, C, E
UniProt : P11142 (HSP7C_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
ATP + H2O = ADP + phosphate + H(+) 3.6.4.10 PubMed:12526792
-
Chain : B, D, F
UniProt : Q99933 (BAG1_HUMAN)
Reaction : -