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Ligands
Code Name Style Show Link
ACT Acetate ion
H4B 5,6,7,8-tetrahydrobiopterin
HEM Protoporphyrin ix containing Fe
RGE (2s)-2-amino-5-(2-(methylsulfinyl)acetimidamido)pentanoic acid
ZN Zinc ion
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Code : 5AGK   PDBj   RCSB PDB   PDBe
Header : OXIDOREDUCTASE
Title : Structure of rat neuronal nitric oxide synthase heme domain in complex with (2S)-2-Amino-5-(2-(methylsulfinyl)acetimidamido) pentanoic acid
Release Data : 2015-04-29
Compound :
mol_id molecule chains synonym
1 NITRIC OXIDE SYNTHASE, BRAIN A,B BNOS, CONSTITUTIVE NOS, NC-NOS, NOS TYPE I, NEURONAL NOS, N-NOS, NNOS, PEPTIDYL-CYSTEINE S-NITROSYLASE NOS1, NEURONAL NITRIC OXIDE SYNTHASE
ec: 1.14.13.39
fragment: HEME DOMAIN, RESIDUES 297-718
Source :
mol_id organism_scientific organism_common expression_system
1 RATTUS NORVEGICUS  (taxid:10116) NORWAY RAT ESCHERICHIA COLI  (taxid:469008)
expression_system_strain: BL21(DE3)
expression_system_vector: PCWORI
Authors : Li, H., Poulos, T.L.
Keywords : OXIDOREDUCTASE, NITRIC OXIDE SYNTHASE, INHIBITOR COMPLEX
Exp. method : X-RAY DIFFRACTION ( 2.000 Å )
Citation :

Mechanism of Inactivation of Neuronal Nitric Oxide Synthase by (S)-2-Amino-5-(2-(Methylthio)Acetimidamido)Pentanoic Acid.

Tang, W.,Li, H.,Doud, E.H.  et al.
(2015)  J.Am.Chem.Soc.  137 : 5980

PubMed: 25874809
DOI: 10.1021/JACS.5B01202

Chain : A, B
UniProt : P29476 (NOS1_RAT)
Reaction: EC: Evidence:
Physiological Direction:
H(+) + 2 L-arginine + 3 NADPH + 4 O2 = 4 H2O + 2 L-citrulline + 3 NADP(+) + 2 nitric oxide 1.14.13.39 PubMed:15548660, PubMed:1712077
left-to-right PubMed:1712077