Het-PDB Navi2 (PDB: 5AFM)

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Ligands
Code	Name	Link
9Z0	4,5-dibromo-N-(3-hydroxypropyl)-1h-pyrrole-2-carboxamide	PoSSuM
GOL	Glycerol	PoSSuM
L0B	Alpha-lobeline	PoSSuM
NAG	2-acetamido-2-deoxy-beta-D-glucopyranose	PoSSuM

Non-standard Residues
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Glycosylation
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Download interaction data: 5AFM

Code :

5AFM PDBj RCSB PDB PDBe

Header :

TRANSPORT PROTEIN

Title :

alpha7-AChBP in complex with lobeline and fragment 4

Release Data :

2015-05-06

Compound :

mol_id	molecule	chains	synonym
1	ACETYLCHOLINE-BINDING PROTEIN, NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-7	A,C,D,E	ALPHA7-ACHBP, ACH-BINDING PROTEIN, ACHBP

mol_id	molecule	chains	synonym
2	ACETYLCHOLINE-BINDING PROTEIN, NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-7	B	ALPHA7-ACHBP, ACH-BINDING PROTEIN, ACHBP

Source :

mol_id	organism_scientific	organism_common	expression_system
1	LYMNAEA STAGNALIS (taxid:6523)	GREAT POND SNAIL	SPODOPTERA FRUGIPERDA (taxid:7108)
	expression_system_common: FALL ARMYWORM expression_system_cell_line: Sf21

mol_id	organism_scientific	organism_common	expression_system
2	LYMNAEA STAGNALIS (taxid:6523)	GREAT POND SNAIL	SPODOPTERA FRUGIPERDA (taxid:7108)
	expression_system_common: FALL ARMYWORM expression_system_cell_line: Sf21

Authors :

Spurny, R., Debaveye, S., Farinha, A., Veys, K., Gossas, T., Atack, J., Bertrand, D., Kemp, J., Vos, A., Danielson, U.H., Tresadern, G., Ulens, C.

Keywords :

TRANSPORT PROTEIN, PENTAMERIC LIGAND-GATED ION CHANNELS, CYS-LOOP RECEPTOR, NICOTINIC ACETYLCHOLINE RECEPTOR, ALLOSTERIC MODULATION, DRUG DISCOVERY

Exp. method :

X-RAY DIFFRACTION ( 2.85 Å )

Citation :

Molecular Blueprint of Allosteric Binding Sites in a Homologue of the Agonist-Binding Domain of the Alpha7 Nicotinic Acetylcholine Receptor.

Spurny, R.,Debaveye, S.,Farinha, A. et al.
(2015) Proc.Natl.Acad.Sci.USA 112 : E2543

PDB ID: 5AFM