PDB ID: 5AB9
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Structure summary
Code : | 5AB9 PDBj RCSB PDB PDBe | ||||||||||||
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Header : | TRANSCRIPTION | ||||||||||||
Title : | Structure of the p53 cancer mutant Y220C with bound small molecule 7- ethyl-3-(piperidin-4-yl)-1H-indole | ||||||||||||
Release Data : | 2015-12-16 | ||||||||||||
Compound : |
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Source : |
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Authors : | Joerger, A.C. | ||||||||||||
Keywords : | TRANSCRIPTION, CANCER, TUMOR SUPPRESSION, DNA BINDING, CANCER THERAPY, SMALL-MOLECULE STABILIZERS, MOLECULAR CHAPERONE | ||||||||||||
Exp. method : | X-RAY DIFFRACTION ( 1.360 Å ) | ||||||||||||
Citation : |
Exploiting Transient Protein States for the Design of Small-Molecule Stabilizers of Mutant P53.
Joerger, A.C.,Bauer, M.R.,Wilcken, R.
et al.
PubMed: 26636255 |
Reaction
Chain : | A, B |
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UniProt : | P04637 (P53_HUMAN) |
Reaction : | - |