Brand  (β version)

PDB ID: 5A8X

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Ligands
Code Name Style Show Link
IUY Ethyl (5r)-5-(4-cyanophenyl)-7-methyl-8-[3-(trifluoromethyl)phenyl]-1,5-dihydroimidazo[1,2-a]pyrimidin-4-ium-6-carboxylate PoSSuM
Non-standard Residues
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Glycosylation
Code Name Emphasize
FUC Alpha-L-fucopyranose
NAG 2-acetamido-2-deoxy-beta-D-glucopyranose
Modification
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Structure summary

Code : 5A8X   PDBj   RCSB PDB   PDBe
Header : HYDROLASE
Title : Crystal Structure of human neutrophil elastase in complex with a dihydropyrimidone inhibitor
Release Data : 2016-08-03
Compound :
mol_id molecule chains synonym
1 Neutrophil elastase A Bone marrow serine protease,Elastase-2,Human leukocyte elastase,HLE,Medullasin,PMN elastase
ec: 3.4.21.37
other_details: purchased comercially
Source :
mol_id organism_scientific organism_common
1 Homo sapiens  (taxid:9606) Human
Authors : vonNussbaum, F., Li, V.M., Meibom, D., Anlauf, S., Bechem, M., Delbeck, M., Gerisch, M., Harrenga, A., Karthaus, D., Lang, D., Lustig, K., Mittendorf, J., Schaefer, M., Schaefer, S., Schamberger, J.
Keywords : TRYPSIN FAMILY FOLD, PROTEASE, HYDROLASE, HYDROLASE- INHIBITOR COMPLEX
Exp. method : X-RAY DIFFRACTION ( 2.23 Å )
Citation :

Potent and Selective Human Neutrophil Elastase Inhibitors with Novel Equatorial Ring Topology: in vivo Efficacy of the Polar Pyrimidopyridazine BAY-8040 in a Pulmonary Arterial Hypertension Rat Model.

von Nussbaum, F.,Li, V.M.,Meibom, D.  et al.
(2016)  ChemMedChem  11 : 199 - 206

PubMed: 26333652
DOI: 10.1002/cmdc.201500269

Reaction

Chain : A
UniProt : P08246 (ELNE_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
Hydrolysis of proteins, including elastin. Preferential cleavage: Val-|-Xaa > Ala-|-Xaa. 3.4.21.37 PubMed:36899106
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