PDB ID: 5A09
Hetero Atom Contents
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Code | Name | Style | Show | Link | |
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JJD | 2-[(4r)-4-(4-cyanophenyl)-5-ethanoyl-6-methyl-2-oxidanylidene-1-[3-(trifluoromethyl)phenyl]-4h-pyrimidin-3-yl]ethanoic acid | PoSSuM |
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FUC | Alpha-L-fucopyranose | |
NAG | 2-acetamido-2-deoxy-beta-D-glucopyranose |
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Download interaction data: 5A09
Structure summary
Code : | 5A09 PDBj RCSB PDB PDBe | ||||||||||||
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Header : | HYDROLASE | ||||||||||||
Title : | Crystal Structure of human neutrophil elastase in complex with a dihydropyrimidone inhibitor | ||||||||||||
Release Data : | 2015-08-19 | ||||||||||||
Compound : |
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Source : |
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Authors : | vonNussbaum, F., Li, V.M.-J., Allerheiligen, S., Anlauf, S., Baerfacker, L., Bechem, M., Delbeck, M., Fitzgerald, M.F., Gerisch, M., Gielen-Haertwig, H., Haning, H., Karthaus, D., Lang, D., Lustig, K., Meibom, D., Mittendorf, J., Rosentreter, U., Schaefer, M., Schaefer, S., Schamberger, J., Telan, L.A., Tersteegen, A. | ||||||||||||
Keywords : | TRYPSIN FAMILY FOLD, PROTEASE, HYDROLASE, HYDROLASE- INHIBITOR COMPLEX | ||||||||||||
Exp. method : | X-RAY DIFFRACTION ( 1.81 Å ) | ||||||||||||
Citation : |
Freezing the Bioactive Conformation to Boost Potency: The Identification of BAY 85-8501, a Selective and Potent Inhibitor of Human Neutrophil Elastase for Pulmonary Diseases.
von Nussbaum, F.,Li, V.M.,Allerheiligen, S.
et al.
PubMed: 26083237 |
Reaction
Chain : | A | ||||||||
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UniProt : | P08246 (ELNE_HUMAN) | ||||||||
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