PDB ID: 4ZZX
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Structure summary
Code : | 4ZZX PDBj RCSB PDB PDBe | ||||||||||||
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Header : | TRANSFERASE | ||||||||||||
Title : | Structure of PARP2 catalytic domain bound to an isoindolinone inhibitor | ||||||||||||
Release Data : | 2015-08-12 | ||||||||||||
Compound : |
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Source : |
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Authors : | Casale, E., Fasolini, M., Papeo, G., Posteri, H., Borghi, D., Busel, A.A., Caprera, F., Ciomei, M., Cirla, A., Corti, E., DAnello, M., Fasolini, M., Felder, E.R., Forte, B., Galvani, A., Isacchi, A., Khvat, A., Krasavin, M.Y., Lupi, R., Orsini, P., Perego, R., Pesenti, E., Pezzetta, D., Rainoldi, S., RiccardiSirtori, F., Scolaro, A., Sola, F., Zuccotto, F., Donati, D., Montagnoli, A. | ||||||||||||
Keywords : | TRANSFERASE | ||||||||||||
Exp. method : | X-RAY DIFFRACTION ( 1.65 Å ) | ||||||||||||
Citation : |
Discovery of 2-[1-(4,4-Difluorocyclohexyl)Piperidin-4-Yl]-6-Fluoro-3-Oxo-2,3-Dihydro-1H-Isoindole-4-Carboxamide (Nms-P118): A Potent, Orally Available and Highly Selective Parp- 1 Inhibitor for Cancer Therapy.
Papeo, G.M.E.,Posteri, H.,Borghi, D.
et al.
PubMed: 26222319 |
Reaction
Chain : | A, B | |||||||||||||||||||||
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UniProt : | Q9UGN5 (PARP2_HUMAN) | |||||||||||||||||||||
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