Brand  (β version)

PDB ID: 4ZZN

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Ligands
Code Name Style Show Link
CQ8 2-[[5-chloranyl-2-(oxan-4-ylamino)pyridin-4-yl]amino]-N-methyl-benzamide PoSSuM
SO4 Sulfate ion PoSSuM
Non-standard Residues
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CME S,S-(2-hydroxyethyl)thiocysteine
Glycosylation
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Modification
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Structure summary

Code : 4ZZN   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE
Title : Human ERK2 in complex with an inhibitor
Release Data : 2015-05-27
Compound :
mol_id molecule chains synonym
1 MITOGEN-ACTIVATED PROTEIN KINASE 1 A MAP KINASE 1, MAPK 1, ERT1, EXTRACELLULAR SIGNAL-REGULATED KINASE 2, ERK-2, MAP KINASE ISOFORM P42, P42-MAPK, MITOGEN-ACTIVATED PROTEIN KINASE 2, MAP KINASE 2, MAPK 2
ec: 2.7.11.24
fragment: KINASE DOMAIN, RESIDUES 11-360
other_details: MODIFIED CYS 161 A
Source :
mol_id organism_scientific organism_common expression_system
1 HOMO SAPIENS  (taxid:9606) HUMAN ESCHERICHIA COLI  (taxid:562)
Authors : Ward, R.A., Colclough, N., Challinor, M., Debreczeni, J.E., Eckersley, K., Fairley, G., Feron, L., Flemington, V., Graham, M.A., Greenwood, R., Hopcroft, P., Howard, T.D., James, M., Jones, C.D., Jones, C.R., Renshaw, J., Roberts, K., Snow, L., Tonge, M., Yeung, K.
Keywords : TRANSFERASE
Exp. method : X-RAY DIFFRACTION ( 1.33 Å )
Citation :

Structure-Guided Design of Highly Selective and Potent Covalent Inhibitors of Erk1/2.

Ward, R.A.,Colclough, N.,Challinor, M.  et al.
(2015)  J.Med.Chem.  58 : 4790

PubMed: 25977981
DOI: 10.1021/ACS.JMEDCHEM.5B00466

Reaction

Chain : A
UniProt : P28482 (MK01_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein] 2.7.11.24 -
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ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein] 2.7.11.24 -
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