Brand  (β version)

color scheme of protein:

hetatm:
centroid:

chain: Hide other chain(s)

Ligands
Code Name Link
AO Acridine orange
ZN Zinc ion
FAD Flavin-adenine dinucleotide
Code : 4ZVL
Header : Oxidoreductase/Inhibitor
Title : Oxidized quinone reductase 2 in complex with acridine orange
Release Data : 2016-04-06
Compound :
mol_id molecule chains synonym
1 Ribosyldihydronicotinamide dehydrogenase [quinone] A,B NRH dehydrogenase [quinone] 2,NRH:quinone oxidoreductase 2,Quinone reductase 2,QR2
ec: 1.10.99.2
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:469008)
gene: NQO2, NMOR2
expression_system_strain: BL21(DE3)
expression_system_vector_type: plasmid
expression_system_plasmid: pProEXhta
Authors : Leung, K.K., Shilton, B.H.
Keywords : quinone reductase 2, acridine orange, Oxidoreductase-Inhibitor complex
Exp. method : X-RAY DIFFRACTION ( 1.8990 Å )
Citation :

Binding of DNA-Intercalating Agents to Oxidized and Reduced Quinone Reductase 2.

Leung, K.K.,Shilton, B.H.
(2015)  Biochemistry  54 : 7438 - 7448

PubMed: 26636353
DOI: 10.1021/acs.biochem.5b00884

Chain : A, B
UniProt : P16083 (NQO2_HUMAN)
Reaction : 1-(beta-D-ribofuranosyl)-1,4- dihydronicotinamide + a quinone = 1-(beta-D- ribofuranosyl)nicotinamide + a quinol.