Het-PDB Navi2 (PDB: 4ZQD)

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Ligands
Code	Name		Style	Show	Link
0X3	N-(3-chloro-5-fluorophenyl)-4-nitro-2,1,3-benzoxadiazol-5-amine				PoSSuM

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Download interaction data: 4ZQD

Code :

4ZQD PDBj RCSB PDB PDBe

Header :

PROTEIN TRANSPORT/TRANSCRIPTION

Title :

Crystal Structure of the Heterodimeric HIF-2a:ARNT Complex with the Benzoxadiazole Antagonist 0X3

Release Data :

2015-08-12

Compound :

mol_id	molecule	chains	synonym
1	Aryl hydrocarbon receptor nuclear translocator	A,C	ARNT protein, Dioxin receptor, nuclear translocator, Hypoxia-inducible factor 1-beta, HIF1-beta
	fragment: UNP residues 82-464

mol_id	molecule	chains	synonym
2	Endothelial PAS domain-containing protein 1	B,D	EPAS-1, HIF-1-alpha-like factor, mHLF, HIF-related factor, HRF, Hypoxia-inducible factor 2-alpha, HIF2-alpha
	fragment: UNP residues 3-361

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Mus musculus (taxid:10090)	Mouse	Escherichia coli BL21 (taxid:511693)
	gene: Arnt expression_system_vector_type: plasmid expression_system_plasmid: pMKH

mol_id	organism_scientific	organism_common	expression_system
2	Mus musculus (taxid:10090)	Mouse	Escherichia coli BL21 (taxid:511693)
	gene: Epas1, Hif2a expression_system_vector_type: plasmid expression_system_plasmid: pSJ2

Authors :

Wu, D., Potluri, N., Lu, J., Kim, Y., Rastinejad, F.

Keywords :

ARNT, HIF-2a, 0X3, bHLH-PAS, PROTEIN TRANSPORT-TRANSCRIPTION complex

Exp. method :

X-RAY DIFFRACTION ( 2.87 Å )

Citation :

Structural integration in hypoxia-inducible factors.

Wu, D.,Potluri, N.,Lu, J. et al.
(2015) Nature 524 : 303 - 308

PDB ID: 4ZQD