Brand  (β version)

PDB ID: 4ZDQ

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Ligands
Code Name Style Show Link
CTP Cytidine-5'-triphosphate PoSSuM
MG Magnesium ion PoSSuM
ACT Acetate ion PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 4ZDQ   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE
Title : Crystal Structure of 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase (IspD) from Burkholderia thailandensis complexed with CTP
Release Data : 2015-04-29
Compound :
mol_id molecule chains synonym
1 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase A,B,C,D 4-diphosphocytidyl-2C-methyl-D-erythritol synthase,MEP cytidylyltransferase,MCT
ec: 2.7.7.60
fragment: ButhA.00168.a.A1
Source :
mol_id organism_scientific expression_system
1 Burkholderia thailandensis  (taxid:271848) Escherichia coli  (taxid:469008)
strain: E264 / ATCC 700388 / DSM 13276 / CIP 106301
gene: ispD, BTH_I2089
expression_system_strain: BL21(DE3)
expression_system_vector_type: plasmid
expression_system_plasmid: ButhA.00168.a.A1
Authors : Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Keywords : SSGCID, isoprenoid biosynthesis, transferase, Structural Genomics, Seattle Structural Genomics Center for Infectious Disease
Exp. method : X-RAY DIFFRACTION ( 2.3000 Å )
Citation :

Crystal structure and biophysical characterization of IspD from Burkholderia thailandensis and Mycobacterium paratuberculosis.

Pierce, P.G.,Hartnett, B.E.,Laughlin, T.M.  et al.
(2024)  Acta Crystallogr.,Sect.F  80 : 43 - 51

PubMed: 38305785
DOI: 10.1107/S2053230X24000621

Reaction

Chain : A, B, C, D
UniProt : Q2SWT6 (ISPD_BURTA)
Reaction: EC: Evidence:
Physiological Direction:
2-C-methyl-D-erythritol 4-phosphate + CTP + H(+) = 4-CDP-2-C- methyl-D-erythritol + diphosphate 2.7.7.60 HAMAP-Rule:MF_00108
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