Brand  (β version)

PDB ID: 4ZA5

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Ligands
Code Name Style Show Link
4LU 1-deoxy-5-O-phosphono-1-(3,3,4,5-tetramethyl-9,11-dioxo-2,3,8,9,10,11-hexahydro-7h-quinolino[1,8-fg]pteridin-12-ium-7-y L)-D-ribitol PoSSuM
FZZ 1-deoxy-5-O-phosphono-1-[(10ar)-2,2,3,4-tetramethyl-8,10-dioxo-1,2,8,9,10,10a-hexahydro-6h-indeno[1,7-ef]pyrimido[4,5-B][1,4]diazepin-6-yl]-D-ribitol PoSSuM
K Potassium ion PoSSuM
MN Manganese (II) ion PoSSuM
Non-standard Residues
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Structure summary

Code : 4ZA5   PDBj   RCSB PDB   PDBe
Header : LYASE
Title : Structure of A. niger Fdc1 with the prenylated-flavin cofactor in the iminium and ketimine forms.
Release Data : 2015-06-17
Compound :
mol_id molecule chains
1 Fdc1 A
ec: 4.1.1.61
Source :
mol_id organism_scientific expression_system
1 Aspergillus niger  (taxid:5061) Escherichia coli  (taxid:562)
gene: An03g06590
Authors : Payne, K.A.P., Leys, D.
Keywords : (de)carboxylase, prenylated flavin binding, UbiD-type enzyme, lyase
Exp. method : X-RAY DIFFRACTION ( 1.10 Å )
Citation :

New cofactor supports alpha , beta-unsaturated acid decarboxylation via 1,3-dipolar cycloaddition.

Payne, K.A.,White, M.D.,Fisher, K.  et al.
(2015)  Nature  522 : 502 - 506

PubMed: 26083754
DOI: 10.1038/nature14560

Reaction

Chain : A
UniProt : A2QHE5 (FDC1_ASPNC)
Reaction: EC: Evidence:
Physiological Direction:
(E)-4-coumarate + H(+) = 4-hydroxystyrene + CO2 4.1.1.102 HAMAP-Rule:MF_03196
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(E)-cinnamate + H(+) = CO2 + styrene 4.1.1.102 HAMAP- Rule:MF_03196, PubMed:26083743
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(E)-ferulate + H(+) = 2-methoxy-4-vinylphenol + CO2 4.1.1.102 HAMAP-Rule:MF_03196
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