Het-PDB Navi2 (PDB: 4YXR)

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Ligands
Code	Name		Style	Show	Link
0RW	3-methyl-2h-indazole				PoSSuM

Non-standard Residues
Code	Name	Show
SEP	Phosphoserine
TPO	Phosphothreonine

Glycosylation
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Modification
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Download interaction data: 4YXR

Code :

4YXR PDBj RCSB PDB PDBe

Header :

TRANSFERASE

Title :

CRYSTAL STRUCTURE OF PKA IN COMPLEX WITH inhibitor.

Release Data :

2015-05-27

Compound :

mol_id	molecule	chains	synonym
1	cAMP-dependent protein kinase catalytic subunit alpha	A	PKA C-alpha
	ec: 2.7.11.11 other_details: ALPHA ISOENZYME

mol_id	molecule	chains	synonym
2	cAMP-dependent protein kinase inhibitor alpha	I	PKI-alpha
	other_details: ALPHA ISOENZYME

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Bos taurus (taxid:9913)	Bovine	Escherichia coli (taxid:562)
	gene: PRKACA

mol_id	organism_scientific	organism_common	expression_system
2	Bos taurus (taxid:9913)	Bovine	Escherichia coli (taxid:562)
	gene: PKIA

Authors :

Schiffer, A., Wendt, K.U.

Keywords :

COMPLEX (PHOSPHOTRANSFERASE-INHIBITOR) complex, transferase

Exp. method :

X-RAY DIFFRACTION ( 2.00 Å )

Citation :

A combination of spin diffusion methods for the determination of protein-ligand complex structural ensembles.

Pilger, J.,Mazur, A.,Monecke, P. et al.
(2015) Angew.Chem.Int.Ed.Engl. 54 : 6511 - 6515

Chain :

UniProt :

P00517 (KAPCA_BOVIN)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]	2.7.11.11	-
	-	-
ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]	2.7.11.11	-
	-	-

PDB ID: 4YXR