Brand  (β version)

PDB ID: 4YTM

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Ligands
Code Name Style Show Link
MLI Malonate ion PoSSuM
FAD Flavin-adenine dinucleotide PoSSuM
FES Fe2/s2 (inorganic) cluster PoSSuM
SF4 Iron/sulfur cluster PoSSuM
F3S Fe3-s4 cluster PoSSuM
HEM Protoporphyrin ix containing Fe PoSSuM
F6A N-biphenyl-3-yl-2-(trifluoromethyl)benzamide PoSSuM
EPH L-alpha-phosphatidyl-beta-oleoyl-gamma-palmitoyl-phosphatidylethanolamine PoSSuM
Non-standard Residues
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Structure summary

Code : 4YTM   PDBj   RCSB PDB   PDBe
Header : OXIDOREDUCTASE/OXIDOREDUCTASE INHIBITOR
Title : Crystal structure of Mitochondrial rhodoquinol-fumarate reductase from Ascaris suum with N-biphenyl-3-yl-2-(trifluoromethyl)benzamide
Release Data : 2015-08-05
Compound :
mol_id molecule chains synonym
1 Succinate dehydrogenase flavoprotein A,E RHODOQUINOL-FUMARATE REDUCTASE FP SUBUNIT
mol_id molecule chains synonym
2 Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial B,F RHODOQUINOL-FUMARATE REDUCTASE IP SUBUNIT
ec: 1.3.5.1
mol_id molecule chains synonym
3 Cytochrome b-large subunit C,G RHODOQUINOL-FUMARATE REDUCTASE CYBL SUBUNIT
mol_id molecule chains synonym
4 Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial D,H CybS,Cytochrome b558 small subunit,Succinate-ubiquinone reductase membrane anchor subunit
Source :
mol_id organism_scientific organism_common
1 Ascaris suum  (taxid:6253) Pig roundworm
mol_id organism_scientific organism_common
2 Ascaris suum  (taxid:6253) Pig roundworm
mol_id organism_scientific organism_common
3 Ascaris suum  (taxid:6253) Pig roundworm
mol_id organism_scientific organism_common
4 Ascaris suum  (taxid:6253) Pig roundworm
Authors : Harada, S., Shiba, T., Sato, D., Yamamoto, A., Nagahama, M., Yone, A., Inaoka, D.K., Sakamoto, K., Inoue, M., Honma, T., Kita, K.
Keywords : OXIDOREDUCTASE, rhodoquinol-fumarate reductase, Complex II, Inhibitor, OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR complex
Exp. method : X-RAY DIFFRACTION ( 3.40 Å )
Citation :

Structural Insights into the Molecular Design of Flutolanil Derivatives Targeted for Fumarate Respiration of Parasite Mitochondria

Inaoka, D.K.,Shiba, T.,Sato, D.  et al.
(2015)  Int J Mol Sci  16 : 15287 - 15308

PubMed: 26198225
DOI: 10.3390/ijms160715287

Reaction

Chain : A, E
UniProt : U1LRQ3
Reaction : -
Chain : B, F
UniProt : O44074 (SDHB_ASCSU)
Reaction: EC: Evidence:
Physiological Direction:
a ubiquinone + succinate = a ubiquinol + fumarate 1.3.5.1 PubMed:10743611, PubMed:12742584, PubMed:17933581, PubMed:26198225, PubMed:2843227, PubMed:7822332, PubMed:8435436
left-to-right PubMed:10743611, PubMed:12742584, PubMed:17933581, PubMed:26198225, PubMed:7822332, PubMed:8435436
a rhodoquinone + succinate = a rhodoquinol + fumarate 1.3.5.1 PubMed:10743611, PubMed:12742584, PubMed:17933581, PubMed:2843227, PubMed:7822332, PubMed:8435436
right-to-left
Chain : C, G
UniProt : P92506 (DHSC_ASCSU)
Reaction : -
Chain : D, H
UniProt : P92507 (DHSD1_ASCSU)
Reaction : -